This article is hyped up B.S. to sell eyeballs.
Coeliac Disease. Most attention to anti-transglutaminase antibodies is given with respect to Coeliac Disease. A recent study of children published in 2007 demonstrated that the level of ATA in correlates with the scalar Marsh score for the disease in the same patient. See the Coeliac wiki article for more information.
Inflammatory bowel disease. A study published in Nature in 2001 found high levels of anti-transglutaminase antibodies in Inflammatory Bowel Disease - specifically in Crohn's Disease and Ulcerative rectocolitis.
Arthritis. Studies of patients with various forms of arthritis showed highly increased frequencies of antibodies against guinea pig transglutaminase, human recombinant transglutaminase and peptidylarginine deiminase type 4 (PAD4). This suggests a potential for crossreactive antibodies between anti-tTG and anti-PAD4.
Juvenile diabetes and anti-tTG. Childhood (male) Type 1 diabetes (T1D) increases the risk for CD and vice versa and the early signs of CD may precede T1D in many cases. A search for CD in juvenile diabates patients revealed that GF diet resulted in some improvements. A elevated number of diabetes patients have ATA along with increased numbers of gluten-specific T-cells.
Asymptomatic ATA+. A recent screening of 7550 Briton's found 87 undetected ATA+. In this study a 50% increase of ATA was associated with:
* lower bone mineral density of the hip.
* lower hemoglobin levels
* decreased weight.
* lower cholesterol
* higher blood glucose
* increased mortality, particularly to cancer
* greater impairment of neurophysiology (peripheral neuropathies and motor neuron disease.
* increased inflammatory bowel symptoms(not celiac or EMA).
Alcohol consumption. ATA correlated with biomarkers of alcohol consumption, proinflammatory cytokines and markers of fibrogenesis.
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