"Fairly predictive tests for Alzheimer's disease, schizophrenia, depression, some malignancies, heart disease, and most of the rest of the major killers and disablers will probably be in place by 2000 to 2010. Many if not most of these ailments will be assessable in terms of a very sophisticated genetic risk profile which it will be possible to generate in infancy or childhood (or in utero)."
Although multiple biologic interactions among GWAS-identified risk loci and clinical risk factors are likely to contribute to the etiology of many common diseases, this study suggests that the identification of statistical interactions among these factors might have a modest impact on risk prediction and discrimination for common complex diseases.
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