The Luria–Delbrück experiment elegantly demonstrated that in bacteria, genetic mutations arise in the absence of selection, rather than being a response to selection, that is in all of life.The Hershey–Chase experiment showed once and for all that nucleic acids were in fact the heritable molecule in not just T2 phage and E. coli, but indeed all of life.Easily the snarkiest, most badass, and likely most important published scientific paper ever, written as an accessible single page, about the double helix structure of DNA. Jim Watson changed majors from ornithology to genetics after reading What is Life and became Luria's graduate student, while Crick was an older former physicist who also claimed inspiration from Schrödinger. The structure of DNA, and its relationship to function that they discovered, is true for all of life.Soon afterwards the adapter hypothesis and central dogma, both of which are (at least simplistically) true for all of life.
I like the intuitive and pretty library interface, and that iGEM's stuff comes included, but that one can only import sequence files saved in either your own format, .xml, or .gb files but not more accessible text file formats is pretty darn limiting for PhD biologists, much less undergrads or amateurs. My old PI still imports things saved in Microsoft Word 2003 files because that is what they know.Can I really not make folders to organize 'projects' in the library? My Amplify folder has thousands of sequences in it and I haven't even been at this that long.I really like the intuitive and recognisable buttons at the top of the project screen for things like cut and paste, but I can't imagine what I'd use them for. The interface doesn't present nearly enough data at the same time for me to really feel comfortable doing something like primer or vector design and I can't seem to be able to shrink the text size, reduce the spacing between the lines of DNA, or get it to display only the 5' strand to get more to fit. I also really liked the very cute genetic code wheel at the amino acids zoom level but similarly can't imagine what functional purpose it would serve.Can I really not drag and click a selection of DNA with my mouse? Using the arrow keys got old real fast.Can I really not change the project window to scroll left to right rather that up and down?What is up with the shopping cart anyway? Is it a way to buy oligonucleotides? Vectors? If so, where do the Oligos/Vectors come from? Why buy them through you guys?
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