If there was a modest bright spot, it was that Purdue Pharma introduced a tamper-resistant formulation of OxyContin in August 2010; anyone trying to crush the pills to abuse the drug would end up with a gooey, uninjectible gel.
1. Physical/Chemical barriers
2. Agonist/Antagonist combinations
4. Delivery System (including depot injectable formulations and implants)
Not all of that goes into domestic prescription medicine (some is used for research, some is shipped overseas), but since 2004, total amounts for oxycodone, hydrocodone, hydromorphone, and oxymorphone have basically tripled.
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