High consumption of red and processed meat may increase the risk of colorectal cancer in various ways, including the formation of carcinogenic agents. Heterocyclic amines are formed on the surface of meat when it is cooked in direct flame or at high temperatures. N-nitroso compounds are found in foods containing nitrates, or which have been exposed to nitrogen oxides, such as processed meats.There is probably an increased susceptability to toxic effects from HCAs due to inherited N-Acetyltransferase polymorphisms (NAT1 and NAT2) on chromosome 8p21.3-23.1.
For those at higher risk (e.g. with genetic or other lifestyle factors) it may be wise to consider the WCRF's upper limit of 80 g/dayFor the metrically challenged 80g is less than three ounces. Another thing to consider is that the studies correlate more strongly with red meat fat. Therefore, eating processed foods that have artificially increased fat levels compared with unprocessed meats will lower this upper limit significantly. The lifestyle factors include the usual suspects: smoking, lack of exercise, high BMI, high soot particulate environment, high radon level terrain, and so on.
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Catchy.
posted by mr_crash_davis at 6:24 PM on November 23, 2004