In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians.
The most critical factor in the emergence of metabolic diseases is obesity. Adipose tissue modulates metabolism by releasing NEFAs and glycerol, hormones — including leptin and adiponectin — and proinflammatory cytokines. In obesity, the production of many of these products is increased. Retinol-binding protein-4 (RBP4) induces insulin resistance through reduced phosphatidylinositol-3-OH kinase (PI(3)K) signalling in muscle and enhanced expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase in the liver through
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