For decades, scientists believed the main cause of depression was low levels of the neurotransmitters serotonin and norepinephrine. Newer research, however, focuses on the nerve cells themselves and how the brain's circuitry can be permanently damaged by hyperactive stress responses, brought on by genetic predisposition, prolonged exposure to stress or even a single traumatic event. "When the stress responses are stuck in the 'on' position, that has a negative effect on mood regulation overall," says Dr. Michael C. Miller, editor of the Harvard Mental Health Letter. A depressed brain is not necessarily underproducing something, says Dr. Thomas Insel, head of the National Institute of Mental Health—it's doing too much.So if I wanted to learn more about these new-fangled medications, where would I look? What are some keywords I would use on Google?
These discoveries have opened up broad new possibilities for treatment. Instead of focusing on boosting neurotransmitters . . . scientists are developing medications that block the production of excess stress chemicals, hoping to reduce damage to otherwise healthy nerve cells.
I curled in on myself -- the fact that I could not pull myself out of the pit was proof that I deserved to be there in pain. I wasn't suicidal because that would end my pain, and I deserved to suffer -- and those around me I'd fooled into loving me would only suffer in my place (because I'd never let them see that they were wasting their love on me).Without one hint of offence intended nor ill intentions, that has to be the most convoluted thought I met in a while.
Without one hint of offense intended nor ill intentions, that has to be the most convoluted thought I met in a while.No offense taken. One of the things that makes depression a mental illness is that the sufferer can be in an incredibly messed up condition and not be able to recognize the flawed nature of the reasoning. I had a few people call me on it. They'd ask "give me an example of what makes you a terrible person" and I couldn't come up with anything worse than petty human flaws, but that didn't stop me from believing I was a sub-human wretch anyway. It was just axiomatic.
It can be overcome :D !It can, but it's not easy. I'm more than aware that I'm prone to relapse. I've been fighting this since I was a kid, and am likely to be fighting it the rest of my life. Probably the most successful tactic (and the hardest to implement) was going to a set of friends and explaining to them what I go through and what the warning signs are -- and then I trust them to catch it, and to call me on the destructive impulses before I internalize them. It still bothers me to do it ("If you were a better/stronger person you wouldn't need pills to be normal; what right do you have to complicate other people's lives with your problems..."), but, amazingly enough, they don't despise me for needing to lean on them sometimes. Sometimes just knowing there's someone there to catch me keeps me from falling.
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-Demystifying Depression part 1, part 2, a personal essay on depression by Name of Feather on Kuro5hin.
-A criticism of the aforementioned essay on Mind Hacks.
-The satirical yet still spot-on How to Be Depressed.
-Why Intelligent People Tend to Be Unhappy.
-CrazyMeds, a refreshingly honest discussion site about pills for the mentally interesting.
posted by goodnewsfortheinsane at 7:46 PM on March 11, 2007