The Drug Awareness Warning Network Annual Report, published by the US federal government contains a statistical compilation of all drug deaths which occur in the United States. According to this report, there has never been a death recorded from the use of marijuana by natural causes.
According to the Merck Index, the LD50 (dosage lethal to 50% of rats tested) of Δ9-THC by inhalation is 42 mg/kg of body weight. That is the equivalent of a 165 lb (75 kg) man inhaling the THC found in 21 one-gram cigarettes of extremely high-potency (15% THC) marijuana all in one sitting, assuming no THC is lost through smoke loss or absorption by the lungs. For oral consumption, the LD50 for male rats is 1270 mg/kg, and 730 mg/kg for females—equivalent to the THC in about a pound of 15% THC marijuana. The ratio of cannabis material required to saturate cannabinoid receptors to the amount required for a fatal overdose is 1:40,000. There have been no reported deaths or permanent injuries sustained as a result of a marijuana overdose. It is practically impossible to overdose on marijuana, as the user would certainly either fall asleep or otherwise become incapacitated from the effects of the drug before being able to consume enough THC to be mortally toxic.
"The Edge... there is no honest way to explain it because the only people who really know where it is are the ones who have gone over."
-Hunter S. Thompson
Phallolysin, a protein from Amanita phalloides with cytolytic effects in vitro, was highly toxic when given intravenously to rats, mice, rabbits and guinea pigs:
LD50 in rats was 0.05 mg/kg
LD50 in rats was 280 mg/kg
Sanchez also said he took the marijuana "off the street from unknown persons,"
"I questioned him in detail about how many times and what types of narcotics he seized without arrest," the report said.
"I think the State's Attorney is going to get wind of this and talk to the Chief-of-Police and say 'What the heck is going on here?.' Unless there is some kind of evidentiary issue or statue-of-limitations issue this case should go forward. The evidentiary issue I think has gone out the window...I mean...the evidentiary is...yea...'We don't have the pot.' You don't need it because you've got the confession. And, the cocaine, you don't have that either. You know what? I don't think it's going to be that hard to prove that there was cocaine in the car that was for the drug-sniffing dog that she admitted she took. You know, this is not brain surgery here."
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