Hróbjartsson and Gøtzsche's conclusion has been criticised on several grounds. Their meta-analysis covered studies into a highly mixed group of conditions : the placebo effect does occur with peripheral disease processes (such as Hypertension, asthma, prostatic hyperplasia, anal fissure, bronchitis) though not for processes reflecting physical disease (such as venous leg ulcers, Crohn’s disease, urinary tract infection chronic heart failure.[95] Placebos also do not work as strongly in clinical trials because the subjects do not know whether they might be getting a real treatment or a sham one. Where studies are made of placebos in which people think they are receiving actual treatment (rather than merely its possibility) the placebo effect has been observed.[96] Other writers have argued that the placebo effect can be reliably demonstrated under appropriate conditions.Obviously, there are going to be some conditions where the placebo effect isn't going to have an effect, and others where it's going to have a strong effect. It's not going to have much of an effect on heart disease, for example, but the effect for depression is very well established. The placebo effect over all clinical trials might not be very strong (for one thing, comparing against a real drug it might be obvious to the patients which one they're getting), but it's certainly a well documented and observed phenomenon when it's tested for directly.
all published 156 clinical trials in which an experimental drug or treatment protocol was compared to a placebo group and an untreated group, and specifically asked whether the placebo group improved compared to the untreated group. [from the Wiki link above]I've emphasized the word "all" up there. You see? We're not talking about some wildcat trials here. To establish that there's a placebo effect, you have to compare it to no treatment, and it turns out that when you do that it doesn't outperform no treatment.
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posted by Artw at 6:02 PM on May 9, 2009 [1 favorite]