Btw, some time ago, in an askme thread, I suggested that psorasis had a fairly important psychological part. What struck me then was that people really didn't buy it.
never needs winding
Never needs winding
never needs winding
Gets rid of blackheads, the heartbreak of psoriasis
Christ, you don't know the meaning of heartbreak, buddy
C'mon, c'mon, c'mon, c'mon
People with one version of a protein called HLA-B*5701 have immune cells that never fully learn this task. A new study published online May 5 in Nature shows how these uneducated cells help keep HIV down...
That can be a problem because these undereducated T cells sometimes mistake normal body proteins for invaders and attack, causing autoimmune diseases such as psoriasis and creating hypersensitivity to some drugs. But these aggressive, undereducated T cells are also better at attacking HIV.
Side effects of topical steroids
Internal side effects
If more than 50g of clobetasol propionate, or 500g of hydrocortisone is used per week, sufficient steroid may be absorbed through the skin to result in adrenal gland suppression and/or eventually Cushing's syndrome.
* Adrenal Gland Suppression.
Topical steroids can suppress the production of natural steroids, which are essential for healthy living. Stopping the steroids suddenly may then result in illness.
* Cushing's Syndrome If large amounts of steroid are absorbed through the skin, fluid retention, raised blood pressure, diabetes etc. may result.
Skin side effects
Local side effects of topical steroids include:
* Skin thinning (atrophy) and stretch marks (striae).
* Easy bruising and tearing of the skin.
* Perioral dermatitis (rash around the mouth).
* Enlarged blood vessels (telangiectasia).
* Susceptibility to skin infections.
* Disguising infection e.g. tinea incognito.
* Allergy to the steroid cream.
The risk of these side effects depends on the strength of the steroid, the length of application, the site treated, and the nature of the skin problem. If you use a potent steroid cream on your face as a moisturiser, you will develop the side effects within a few weeks. If you use 1% hydrocortisone cream on your hands for 25 years, you will have done no harm at all (except for having wasted a lot of money!)
When younger, I would joke that psoriasis was almost like a mutant healing factor. My immune system was "so strong" that it produced more skin cells than I needed. And that is, very basically, how it works. Wolverine's version was more practical, but hey, most people don't have any mutant healing factor at all! ;P
posted by gilrain at 9:12 AM on June 21
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