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January 23, 2012
OxyContin: Purdue Pharma's painful medicine. Among the sellers of opioids, none has been more successful -- or controversial -- than Purdue Pharma, maker of the No. 1 drug in the class: OxyContin, which generated $3.1 billion in revenue in 2010. Purdue and its marketing prowess are the biggest reasons such drugs are now widely prescribed for all sorts of pain, says Dhalla: "Purdue played a very large role in making physicians feel comfortable about opioids." And as we'll see, Purdue's past and present go a long way toward explaining how so many Americans came to be in the grip of potent painkillers.
posted by storybored at 8:53 PM PST - 63 comments
One Hour Per Second
- "In 1 minute 50 seconds of uploads to YouTube, an unlucky person falling through a bottomless pit travels 12,000 miles."
posted by Memo at 7:11 PM PST - 33 comments
is not my original last name. It was changed 300 years ago to Taxali
by a Maharaja in India. My ancestor invented a coin that was difficult to counterfeit and was subsequently knighted Taxali by the Maharaja. It means, "Maker or Steward of The Mint". How serendipitous!! Here I am, 300 years later, honouring my ancestor's achievements and mine and my sister's family name.
posted by unliteral at 4:41 PM PST - 20 comments
Dog Poop Insurance
is a product that would potentially be available for a single-premium at the time of purchasing your new shoes.
posted by gman at 4:01 PM PST - 15 comments
"We were so dumbfounded at the noise that was coming out of our instruments it took us a while to get a handle on what we were hearing, let alone thinking in terms of how any records would be structured." Music journalist Ned Raggett assembles the oral history of British experimental rock group Disco Inferno's five EPs
posted by Houyhnhnm at 2:51 PM PST - 17 comments
"Suppose the null-byte is an electron. Then, /dev/zero provides an infinite supply of electrons and /dev/null has an infinite appetite for them..." Modeling transistors and logic gates using Unix pipes.
posted by bitmage at 1:55 PM PST - 22 comments
On the same day that NJ governor Chris Christie announced
that he has nominated an openly gay African-American Republican mayor to the state’s highest court, Washington state's legislature has announced
that they have the votes to pass the same sex-marriage bill that the governor has already promised to sign. Washington will be the seventh state to have same sex marriages. [more inside]
posted by roomthreeseventeen at 1:24 PM PST - 70 comments
"Inspired by the iconic sleeve of Joy Division's Unknown Pleasures
album, this Waves Mickey Mouse Tee
incorporates Mickey's image within the graphic of the pulse of a star. That's appropriate given few stars have made bigger waves than Mickey!"
posted by obscurator at 11:18 AM PST - 96 comments
A Portrait in Postcards.
Twenty years after her death, Angela Carter's
literary executor and friend, Susannah Clapp
, remembers Carter through the cards she sent, "These cards make a paper trail, a zigzag path through the 80s. They are casually dispatched – some messages are barely more than a signature – but are often the more telling for that: they catch Angela on the wing, shooting her mouth off. She would have hated the idea of a soundbite, but she had a gift for a capsule phrase, for a story in a word. " The postcard gallery.
posted by gladly at 9:55 AM PST - 4 comments
Four days after the shutdown of popular "cyber-locker" Megaupload, rival companies Filesonic
have also disabled file sharing. The two companies also owned wupload, upload.to, and a number of other cyber-locker sites. Is this the end of direct download filesharing?
posted by reformedjerk at 9:08 AM PST - 108 comments
"I love stories. My chief hobby is reading. I was formally trained as a writer, not as a game designer (there wasn’t really any formal training for game design I got started, but that’s another story). I think most game stories are not very good. And I quite enjoy games with narrative threads pulling me through them. When I find a game with a good story, I frequently prefer the story to the actual game! So please keep that in mind as you read: I love story.
Narrative in a game is not a mechanic. It’s a form of a feedback
, by Raph Koster
posted by codacorolla at 8:57 AM PST - 10 comments
"The observers of this unusual visual stimulus reported seeing the borders between the stripes gradually disappear, and the colors seem to flood into each other. Amazingly, the image seemed to override their eyes' opponency mechanism, and they said they perceived colors they'd never seen before."
posted by Slap*Happy at 4:07 AM PST - 30 comments