Down syndrome and Alzheimer's
May 5, 2007 9:26 AM Subscribe
Down syndrome and Alzheimer's. People with Down syndrome are much more likely to develop Alzheimer's, and at a much earlier age: three-quarters of them will get it by the age of 65, compared with one-tenth of the general population. This Globe and Mail article looks at a relatively new phenomenon due, in no small part, to longer life expentancies among those with Down syndrome.
Pulmonary vascular disease is also very common in Down syndrome - increased hypoxia in the brain associated with this morbidity contributes to stabilizing beta-secretase protein and this gene has a hypoxia response element in its promoter which results in increased production of Aß, the toxic (and primary component of neurofibrilary tangles and neuritic plaques seen in Alzheimer's) form of the amyloid precursor protein breakdown product.
posted by porpoise at 11:17 AM on May 5, 2007
posted by porpoise at 11:17 AM on May 5, 2007
It appears I am a tiresome pedant who lives in the UK... In the US it is, strangely, Down Syndrome
posted by A189Nut at 11:41 AM on May 5, 2007
posted by A189Nut at 11:41 AM on May 5, 2007
The title of the article, "Doomed from birth to death," seems to paint a certain representation of life with Down('s) Syndrome.
Certainly, there are medical challenges to having this disease. But are these lives particularly more doomed? Hardly.
posted by gavia at 11:56 AM on May 5, 2007
Certainly, there are medical challenges to having this disease. But are these lives particularly more doomed? Hardly.
posted by gavia at 11:56 AM on May 5, 2007
One TENTH? More like 2-3%, not 10%. Still a horrifyingly scary number, but it isn't one tenth of the population who will have it by age 65.
Good god, that's an even more horrible thought, on top of the already horrible thought that 2-3% will.
posted by FritoKAL at 12:37 PM on May 5, 2007
Good god, that's an even more horrible thought, on top of the already horrible thought that 2-3% will.
posted by FritoKAL at 12:37 PM on May 5, 2007
Nope, the prevalence in individuals aged 65+ is more like 13%, I'm afraid to say.
"The updated estimates, based on the rising occurrences of the disease with age, not new disease research, were released yesterday by the Alzheimer’s Association, along with a compilation of other information about a progressive brain disease that afflicts 13 percent, or one in eight people 65 and over, and 42 percent of those past 85." [NYT]
posted by docgonzo at 1:41 PM on May 5, 2007
"The updated estimates, based on the rising occurrences of the disease with age, not new disease research, were released yesterday by the Alzheimer’s Association, along with a compilation of other information about a progressive brain disease that afflicts 13 percent, or one in eight people 65 and over, and 42 percent of those past 85." [NYT]
posted by docgonzo at 1:41 PM on May 5, 2007
(Note: I should point out that it is in the interest of the Alzheimer's Association to put out as high an estimate as possible; I don't know what their case definition is, either, nor the source of their data.)
posted by docgonzo at 1:42 PM on May 5, 2007
posted by docgonzo at 1:42 PM on May 5, 2007
Here's a better -- and lower -- estimate of prevalences by WHO region from an article in The Lancet.
posted by docgonzo at 1:49 PM on May 5, 2007
posted by docgonzo at 1:49 PM on May 5, 2007
I remember the days when longer life expentancies were cheap.
posted by weapons-grade pandemonium at 2:49 PM on May 5, 2007
posted by weapons-grade pandemonium at 2:49 PM on May 5, 2007
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posted by Blazecock Pileon at 9:44 AM on May 5, 2007