X inactivation is a type of gene dosage compensation. In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development. Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21. In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.
Here is a helpful eleven minute description of what it is and why it's important by Etsuko Uno and metafilter's own Drew Berry in a fucking gorgeous Goodsell-esque 3D animation. [more inside]
posted by Blasdelb
on Sep 14, 2013 -
You know how you had heard there was a cool video out there showing the growth and construction on Capitol Hill rendered in 3D animation and you were all, eh, I'll watch it once somebody puts it on the same page as the Game of Thrones
theme so that I can get the full experience? Well now you have no more excuse.
posted by Navelgazer
on Jul 17, 2013 -
(vimeo) A sci-fi short animated film created by a new Spanish artist, Jesús Orellana. This was a year-long, solo project created without a budget. [more inside]
posted by zarq
on Nov 11, 2011 -
: when your lunch goes berserk. Vimeo; Warning, funny, violent, and gory as Hell, so maybe NSFW. Also available in 3D. [more inside]
posted by bwg
on May 21, 2011 -
Toy Story 3
hits theaters today, and it's already winning universal acclaim
as an enchanting and heartbreaking wonderwork, employing understated 3D
and a "real-time"
perspective that deftly capitalizes on the nostalgia and can't-go-home-again angst
of a generation that grew up with the series.
It has a strong pedigree, with 11-year-old predecessor Toy Story 2
the rare sequel to equal its forebear, 1995's Toy Story
(itself the first CGI feature in history).
And it joins a lofty stable of films: over the last 15 years, Pixar has put out an unbroken chain of ten commercial and critical successes
that have grossed over $5 billion worldwide and collected 24 Academy Awards
(including the second-ever Best Picture nom for animation
), a legacy that rivals some of the greatest franchises in film history
But there's rumbling on the horizon. Although the studio has been hailed for its originality
(of the 50 top-grossing movies in history, only nine were original stories -- and five of them were by Pixar
), two of their upcoming projects are sequels
, both of them based some of their least-acclaimed films (Cars 2
in 2011 and Monsters, Inc. 2
in 2012). And while 2012 will also bring
The Bear and the Bow Brave
, the first Pixar flick to feature a female protagonist [previously]
, fellow newcomer Newt
has been canceled
. With WALL-E/Up/Toy Story 3
guru Andrew Stanton focusing on his 2012 adaptation
of John Carter of Mars
and with forays into live-action
already in development, does this mark the end of the golden age of Pixar?
Or is this latest entry lasting proof that even the toughest case of sequelitis can be raised to the level of masterpiece? [more inside]
posted by Rhaomi
on Jun 18, 2010 -
The Eco Zoo
- some amazing Japanese 3D Flash. If you take a close look at the animals there... you might be able to get some tips to live in a more environmentally friendly way!
posted by Artw
on Sep 13, 2008 -
Peeing robots, rockin' office workers, engaging panoramas, and even a few sexy girls.
posted by artifarce
on Sep 6, 2008 -
"Imagine a blend between a National Geographic documentary and a Tex Avery cartoon. This short is a combination of 3D characters and live footage."
Five-ish minutes in the life of a ladybug with anger issues. (YouTube)
posted by Orb
on Sep 7, 2006 -
, the Oscar winner for Best Short Film, is a canadian 3d and 2d animated masterpiece. I wish I could provide more than the material already provided by Andy Baio, but I just felt like you all should see this. It's the true story of Ryan Landis
, a brilliant artist devastated by the real world. It's also the story of his impact on the director. That really doesn't do it justice. Please just click. apology inside
posted by shmegegge
on Mar 1, 2005 -
Just saw a video from thes folks as a between shows filler on PBS. Remember Herbie Hancock's robotic music video from the mid-80s? This is classical music but even cooler--no hands used in playing--endorsed by Jon Anderson and Alan Parsons.
posted by billsaysthis
on Jul 22, 2004 -
The next wave in Filmmaking?
This summer, the Academy of Machinima Arts & Sciences, along with NVIDIA, will hold the world's first Machinima Film Festival
on August 17th in Mesquite, Texas.
Machinima is, simply stated, filmmaking within a real-time virtual 3D environment.
In an expanded definition, it is the convergence of filmmaking, animation & game development. Machinima is a very cost- & time-efficient way to produce films.
posted by lilboo
on Jul 12, 2002 -