X inactivation is a type of gene dosage compensation. In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development. Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21. In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.
Here is a helpful eleven minute description of what it is and why it's important by Etsuko Uno and metafilter's own Drew Berry in a fucking gorgeous Goodsell-esque 3D animation. [more inside]
The Hidden Life Of the Cell (57:24)
There is a battle playing out inside your body right now. It started billions of years ago and it is still being fought in every one of us every minute of every day. It is the story of a viral infection - the battle for the cell. This film reveals the exquisite machinery of the human cell system from within the inner world of the cell itself - from the frenetic membrane surface that acts as a security system for everything passing in and out of the cell, the dynamic highways that transport cargo across the cell and the remarkable turbines that power the whole cellular world to the amazing nucleus housing DNA and the construction of thousands of different proteins all with unique tasks. The virus intends to commandeer this system to one selfish end: to make more viruses. And they will stop at nothing to achieve their goal. Exploring the very latest ideas about the evolution of life on earth and the bio-chemical processes at the heart of every one of us, and revealing a world smaller than it is possible to comprehend, in a story large enough to fill the biggest imaginations.
You may be familiar with molecular movies from my two previous megaposts collecting them, but this extended documentary uses original animation that is collected into a coherent educational narrative and is just so fucking gorgeous. Enjoy. [more inside]
Bioanimation companies like XVIVO
, Hybrid Medical (Previously)
, Argosy Medical
, and BioDigital
have been doing beautiful work for hire, freely available to watch. [more inside]
There has been a new discipline developing in molecular biology for some time now, Bioanimation! Projects have ranged in size from WEHI
's colossal compilation
to Harvard Biovision
's magnum opus "Inner Life of the Cell"
to commercially produced masterpieces
to smaller projects by university PIs and enthusiasts. much [more inside]