Inside the insectary - "These gene drives, they're able to copy themselves. So instead of half of the offspring inheriting the gene drive, almost all of them do. So what happens is that it spreads and it spreads and it spreads. And this is the fantastic thing. Because it allows that gene to be selfish in a population. And in a very short amount of time you can actually transform an entire wild population into a modified population. It's powerful." (previously: 1,2,3)
"In the winter of 2014, students at Iowa State University received emails asking them to volunteer for an experiment. Researchers were looking for women who would eat bananas that had been genetically engineered to produce extra carotenes, the yellow-orange nutrients that take their name from carrots. Our bodies use alpha and beta carotenes to make retinol, better known as vitamin A, and the experiment was testing how much of the carotenes in the bananas would transform to vitamin A. The researchers were part of an international team trying to end vitamin A deficiency. The emails reached the volunteers they needed to begin the experiment, but they also reached protesters. “As a student in the sustainability program, I immediately started asking questions,” said Iowa State postdoc Rivka Fidel. “Is this proven safe? Have they considered the broader cultural and economic issues?” ... Fidel told me she and her friends had found it nearly impossible to extract information from researchers, or from the Gates Foundation, which is providing funding for this project. Too often conversations about these kinds of issues simply reverberate within their respective echo chambers. So to bridge the gap I took the gist of the students’ questions to people at the Gates Foundation, scientists working on the banana, and the one person who may have done the most to fight vitamin A deficiency — an ophthalmologist who has no interest in either promoting or bashing GMOs." [more inside]
Humans 2.0 - "With CRISPR, scientists can change, delete, and replace genes in any animal, including us. Working mostly with mice, researchers have already deployed the tool to correct the genetic errors responsible for sickle-cell anemia, muscular dystrophy, and the fundamental defect associated with cystic fibrosis. One group has replaced a mutation that causes cataracts; another has destroyed receptors that H.I.V. uses to infiltrate our immune system." [more inside]
'Why People Oppose GMOs Even Though Science Says They Are Safe - Intuition can encourage opinions that are contrary to the facts' (SciAm)
The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
New GM technique injects mosquitoes with a gene that results in mostly male offspring, eventually leading to a population crash. Previous efforts to tackle the disease, that kills more than 1 million people each year – most of whom are African children – have included bed nets to protect people and insecticides to kill the mosquito species most responsible for the transmission of malaria (Anopheles gambiae). The new technique by a team at Imperial College London involves injecting mosquitoes with a gene that causes the vast majority of their offspring to be male, leading to an eventual dramatic decline in population within six generations as females disappear. “You have a short-term benefit because males don’t bite humans [and transmit malaria],” Andrea Crisanti, one of the authors of the new research, which was published in the journal Nature Communications on Tuesday, told the Guardian. “But in the long term you will eventually eradicate or substantially reduce mosquitoes. This could make a substantial contribution to eradicating malaria, combined with other tools such as insecticides.”
These new mosquitoes are now set to be used in Brazil, having been approved for use by the Brazilian government with a factory for their production now opened.[more inside]
Monsanto Is Going Organic in a Quest for the Perfect Veggie - "The lettuce, peppers, and broccoli—plus a melon and an onion, with a watermelon soon to follow—aren't genetically modified at all. Monsanto created all these veggies using good old-fashioned crossbreeding, the same technology that farmers have been using to optimize crops for millennia. That doesn't mean they are low tech, exactly. Stark's division is drawing on Monsanto's accumulated scientific know-how to create vegetables that have all the advantages of genetically modified organisms without any of the Frankenfoods ick factor." [more inside]
The disease that sours oranges and leaves them half green, already ravaging citrus crops across the world, had reached the state’s storied groves. To slow the spread of the bacterium that causes the scourge, they chopped down hundreds of thousands of infected trees and sprayed an expanding array of pesticides on the winged insect that carries it. But the contagion could not be contained.They would have to alter the orange’s DNA — with a gene from a different species. (SLNYT)
With a precipitous decline in Florida’s harvest predicted within the decade, the only chance left to save it, Mr. Kress believed, was one that his industry and others had long avoided for fear of consumer rejection.
Some of My Best Friends Are Germs
It is a striking idea that one of the keys to good health may turn out to involve managing our internal fermentation. Having recently learned to manage several external fermentations — of bread and kimchi and beer — I know a little about the vagaries of that process. You depend on the microbes, and you do your best to align their interests with yours, mainly by feeding them the kinds of things they like to eat — good “substrate.” But absolute control of the process is too much to hope for. It’s a lot more like gardening than governing. The successful gardener has always known you don’t need to master the science of the soil, which is yet another hotbed of microbial fermentation, in order to nourish and nurture it. You just need to know what it likes to eat — basically, organic matter — and how, in a general way, to align your interests with the interests of the microbes and the plants. The gardener also discovers that, when pathogens or pests appear, chemical interventions “work,” that is, solve the immediate problem, but at a cost to the long-term health of the soil and the whole garden. The drive for absolute control leads to unanticipated forms of disorder.[more inside]
Today the British government released a major report on the safety of genetically modified foods. According to New Scientist, "existing genetically modified crops and foods pose a 'very low' risk to human health and are 'very unlikely' to rampage through the British countryside", but others disagree.
It's New, It's Wonderful, it's....No Cry Onions! from the nature.com website, scientists have identified the enzyme that causes a "tickling" of your tear ducts, ergo the ensuing crying. More genetically altered food - how are we feeling about this?
Since Genetically Modified Organisms are a big no-no in Europe, some scientists are now focusing their efforts on TILLING (Targeting Induced Local Lesions in Genomes), a novel technology for rapid selection of a mutation in any gene from mutant plant, through the use of a mutagen, Ethyl Methanesulfonate (EMS). Will this method be seen as less dangerous than Genetic Engineering à la Monsanto? During my search on this topic, I stumbled on this entertaining story about DIY genegeneering.
Glowing Pig News Great to take to parties..... (Hurrah for my first ever link that hasn't been found in previous threads...)