Inside the insectary - "These gene drives, they're able to copy themselves. So instead of half of the offspring inheriting the gene drive, almost all of them do. So what happens is that it spreads and it spreads and it spreads. And this is the fantastic thing. Because it allows that gene to be selfish in a population. And in a very short amount of time you can actually transform an entire wild population into a modified population. It's powerful." (previously: 1,2,3)
Humans 2.0 - "With CRISPR, scientists can change, delete, and replace genes in any animal, including us. Working mostly with mice, researchers have already deployed the tool to correct the genetic errors responsible for sickle-cell anemia, muscular dystrophy, and the fundamental defect associated with cystic fibrosis. One group has replaced a mutation that causes cataracts; another has destroyed receptors that H.I.V. uses to infiltrate our immune system." [more inside]
"Humans as Superorganisms: How Microbes, Viruses, Imprinted Genes and Other Selfish Entities Shape Our Behavior" by Peter Kramer and Paola Bressan discusses the idea that an individual homo sapiens is only one component of the human superorganism we call a person, focusing on the psychological and psychiatric ramifications thereof. (Paola Bressan previously.)
The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
She started by diving into PubMed—an online search engine for biomedical papers—hunting down everything she could on Charcot-Marie-Tooth. She hoped that her brief fling with a scientific education would carry her through. But with pre-med knowledge that had been gathering dust for 30 years and no formal training in genetics, Kim quickly ran head first into a wall of unfamiliar concepts and impenetrable jargon. “It was like reading Chinese,” she says.
Spider webs are incredibly strong and flexible. It’s no surprise, then, that spider silk proteins may someday form durable artificial ligaments for people who have injured their knees or shoulders. Six different kinds of silk are produced by orb-web weaving spiders. These silk fibers have very different mechanical properties that are so effective they have changed very little over millions of years. How to synthetically develop these silks is one focus of Lewis’ research. The secret to producing large quantities of spider silk is to use “factories” designed to manufacture spider silk proteins that are easily scale-able and efficient. Lewis uses transgenic goats, E.coli bacteria, transgenic alfalfa and transgenic silk worms to produce the spider silk proteins used to create spider silk. Spider silk is 100 times stronger than natural ligaments and 10 times stronger than natural tendons; it is stronger than Kevlar and more elastic than nylon.
A 6min brief on the work being done in Laramie, WY whereby spider silk is being spun from goat milk. SPIDERGOATS[more inside]
Just as Dante found it easier to conjure the pains of Hell than to evoke the joys of Heaven, so too do bioethicists find it easier to concoct the possible perils of a biotech-nanotech-infotech future than to appreciate how enhancements will contribute to flourishing lives. One of the chief goals of this symposium is to think about the indispensable role that virtue plays in human life. The chief motivating concern seems to be the fear that biotechnologies and other human enhancement technologies will somehow undermine human virtue. As we will see, far from undermining virtue, biotech, nanotech, and infotech enhancements will tend to support virtue; that is, they will help enable people to be actually good.
How can we better understand the interplay of nature and nurture in determining our personalities, behavior, and vulnerability to disease? Perhaps we should be looking at identical twins. (National Geographic January 2012 cover story) [more inside]
Epidemiology: Study of a lifetime. "In 1946, scientists started tracking thousands of British children born during one cold March week. On their 65th birthday, the study members find themselves more scientifically valuable than ever before." [more inside]
Followup to this post: A US District Court has ruled that Myriad Genetic's patents on breast cancer genes BRCA1 and BRCA2, which allow them to hold exclusive rights to a widely used genetic test for inherited breast and ovarian cancer susceptibility, are invalid. Genomics Law Report analyzes the ruling in two posts. The decision is likely to be challenged in a legal appeal — but if upheld, it could have huge implications for the biotechnology industry. [more inside]
Cracking the Cancer Code: We already know that all cancers are caused by DNA mutations acquired during a person's lifetime. But what mutations actually cause cancer? We may be one step closer to finding out. International research teams led by the Cancer Genome Project at the Wellcome Trust Sanger Institute have now mapped the entire genetic code of two of the most common human cancers: lung and skin (malignant melanoma). Their findings have the potential to revolutionize preventative and treatment therapies as well as pave the way for new early detection tests. More. [more inside]
Interesting developments in med-tech: gene testing machines for doctors, a plan to engineer stem cells to kill HIV, a new way to repair damaged nerves, the next generation of retinal implants, and the first bionic fingers up for sale. (Bonus for those uninterested in medicine: the newest take on a Minority Report-style interface, courtesy of MIT.)
On behalf of medical organizations, universities, & individual patients, pathologists and genetics researchers, the ACLU has filed a lawsuit against Utah-based Myriad Genetics and the US Patent and Trademark Office. Myriad holds the US patents to the BRCA1 and BRCA2 genes, associated with hereditary causes of breast and ovarian cancers. Their patents guarantee the company the right to prevent anyone else from testing or studying those genes, which the ACLU says is unconstitutional and inhibits researchers from finding treatments and cures. [more inside]
Scientists Repurpose Adult Cells - "Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a variety of illnesses and sidestep the political and ethical quagmires associated with embryonic stem cell research." [nature abstract, nature writeup, audio announcement]
U.S. military practices genetic discrimination in denying benefits. "Those medically discharged with genetic diseases are left without disability or retirement benefits. Some are fighting back."
In terms of our genes, we humans are all the same -- except for the ways in which we're different. Pharmacogenomics has for years been touted as the ultimate benefit of the genomics revolution. But to many, this revolution has a troubling side.
Two of his children dying from a rare genetic disorder, Dad -- with no science background whatever -- starts a biotech company for the sole purpose of developing a drug that will cure them. Heartrending conflicts ensue. "Many times, I'd be talking aloud about programs and budgets, and at the back of my mind be thinking, 'Oh my God, this is not good for Megan and Patrick.' "
In lieu of today's posts on GM foods and meat, Trans Ova Genetics is pharming cows in hopes of creating one capable of adminstering human antibodies.
Are heart disease, cancer and schizophrenia caused by pathogens? The logic basically goes that a genetic disease cannot have a very high rate of occurrence as natural selection would prevent that gene from surviving (leaving the few occurrences of the disease that are caused by random mutation). Also: how to make diseases more benign by altering the parameters to their natural selection.