Your body is home to about 100 trillion bacteria and other microbes, collectively known as your microbiome. Naturalists first became aware of our invisible lodgers in the 1600s
, but it wasn’t until the past few years that we’ve become really familiar with them. This recent research has given the microbiome a cuddly kind of fame.
We’ve come to appreciate how beneficial our microbes are — breaking down our food, fighting off infections and nurturing our immune system. It’s a lovely, invisible garden we should be tending for our own well-being. But in the journal Bioessays, a team of scientists has raised a creepier possibility.
Perhaps our menagerie of germs is also influencing our behavior in order to advance its own evolutionary success — giving us cravings for certain foods, for example.
Maybe the microbiome is our puppet master. [more inside]
The Animated Genome
is a spirited 5-minute film that uses graphics to explain the makeup of your genome and how it affects life and health. It's part of Genome: Unlocking Life's Code
, an exhibition at the Smithsonian Institution National Museum of Natural History
In 2001, we learned the sequence of our genome; now, we have amassed a vast amount of knowledge about what those sequences actually do
. Yesterday, the data from the ENCODE
project went live. [more inside]
A hive plot
) is a beautiful and compelling way to visualize multiple, complex networks, without resorting to "hairball
" graphs that are often difficult to qualitatively compare and contrast. [more inside]
The New Biology
- Eric Schadt's quest to upend molecular biology and open source it. (via
An Icelandic company called deCODE genetics
) has found evidence, though not conclusive, that an unknown American woman traveled to Iceland, possibly against her will, as early the year 1000
but not later than 1700. She had offspring in Iceland with natives. 80 of her descendants are still extant in that country. This finding has been announced in a pre-print online publication of the
American Journal of Physical Anthropology
. The work involved explorations of mitochondrial DNA
, which are frequently employed to examine humans' centuries-old lineages. One surprising result is that this lineage does not seem to line up with previously known Native American genetic markers, but the authors believe that the explanation above is "[more] likely" than this common ancestor being European or Asian. (Via Daily Mail
.) [more inside]
"The ability to design and create new forms of life marks a turning-point in the history of our species and our planet."
- Freeman Dyson, on the J.C. Venter Institute's creation of a cell controlled by a synthetic genome. We are now in the business of engineering life.
Followup to this post:
A US District Court has ruled
that Myriad Genetic's patents on breast cancer genes BRCA1 and BRCA2, which allow them to hold exclusive rights
to a widely used genetic test for inherited breast and ovarian cancer susceptibility, are invalid
. Genomics Law Report analyzes the ruling
in two posts
. The decision is likely to be challenged in a legal appeal — but if upheld, it could have huge implications for the biotechnology industry. [more inside]
We may soon be able to clone Neanderthals. But should we
? An essay from Archaeology Magazine examines the ethical, scientific and legal ramifications. (Via Heather Pringle's Time Machine blog, where essay author Zach Zorich posted a reply and elicited a response.) [more inside]
Cracking the Cancer Code:
We already know that all cancers are caused by DNA mutations acquired during a person's lifetime. But what mutations actually cause cancer? We may be one step closer to finding out. International research teams led by the Cancer Genome Project at the Wellcome Trust Sanger Institute have now mapped
the entire genetic code
of two of the most common human cancers: lung and skin (malignant melanoma).
Their findings have the potential
to revolutionize preventative and treatment therapies as well as pave the way for new early detection tests. More
. [more inside]
I.B.M. Joins Pursuit of $1,000 Personal Genome
The target is remarkable given that the original Human Genome Project
successfully sequenced the first genome less than ten years ago and cost roughly $500 million to $1 billion. Advances in sequencing technology puts Moore's Law to shame: "In the last four to five years, the cost of sequencing has been falling at a rate of tenfold annually, according to George M. Church, a Harvard geneticist. In a recent presentation in Los Angeles, Dr. Church said he expected the industry to stay on that curve, or some fraction of that improvement rate, for the foreseeable future.
" [more inside]
My Genome, My Self:
Steven Pinker considers what we can expect from personal genomics
. Searching for Intelligence in Our Genes:
Carl Zimmer looks at the hunt to learn about the role of genes in intelligence.
- "a comprehensive source for the latest research, news and events in neuroscience and genomics research"
The all-new sneeze-free cat
this week joins a distinguished roster of altered organisms, such as glowing green pigs
, and even a potato with a bacterial pesticide spliced in
. And don't forget OraGenics
, the company that wants to infect your teeth with bacteria that won't cause decay - and will crowd out the ones that do. Brave New World
, indeed. What's next?
DNA used to ascertain race of unidentified serial killer.
Florida company DNAPrint Genomics claims their test can identify the race (ie, African, Caucasian, East Asian or American Indian) of a person from their DNA. CEO Tony Frudakis says
that "of over 2,200 blind samples tested, the test is yet to get one wrong."