In a recent paper published in Nature Hansen et al. show the efficacy of their unusual vaccine strategy against SIVMAC239 in rhesus macaques. While the goal is not necessarily to produce a human vaccine against HIV using this exact strategy, this paper is now reigniting the debate over the progression of HIV infections and the mechanism(s) by which the virus skirts the human immune system.
The HIV ancestor virus, SIV, has been around much longer than previously thought. The NY Times notes: "And that assumption in turn complicates a question that has bedeviled AIDS scientists for years: What happened in Africa in the early 20th century that let a mild monkey disease move into humans, mutate to become highly transmissible and then explode into one of history’s great killers, one that has claimed 25 million lives so far?" [more inside]
AIDS really did come from chimps in the 1950s --..."We're 25 years into this pandemic," Hahn said. "We don't have a cure. We don't have a vaccine. But we know where it came from. At least we can make a check mark on one of those." ... ...Identifying the source of the HIV pandemic is more than filling in a missing link in the disease's progression. ...
The Hunt for the Origin of AIDS "The notion that AIDS arose from a polio vaccine made with contaminated chimpanzee cells is far from the only theory about how the epidemic started, and it is hotly disputed. The quest for the source of the epidemic is intensifying, as researchers scour the jungle for clues and try to "walk back" the disease genetically with the help of the world's most powerful computers."