Humans 2.0 - "With CRISPR, scientists can change, delete, and replace genes in any animal, including us. Working mostly with mice, researchers have already deployed the tool to correct the genetic errors responsible for sickle-cell anemia, muscular dystrophy, and the fundamental defect associated with cystic fibrosis. One group has replaced a mutation that causes cataracts; another has destroyed receptors that H.I.V. uses to infiltrate our immune system." [more inside]
The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
Fish oil: it's been touted as a solution to heart health, dementia, glaucoma, and a host of other ailments. Unfortunately, it turns out that most of the evidence for its benefits is equivocal at best. And it turns out that fish oil isn't particularly useful for our pets, either. Worse, it turns out that the foundational study that kicked off interest in fish oil as a supplement is not quite as promising for fish oils as it is usually construed and cited. Given that fish oil can induce strokes in high quantities (and may interfere with treatments like chemotherapy), is poorly regulated, and is expensive, should we be promoting fish oil supplements as strongly as we do?
"Postpartum depression isn’t always postpartum. It isn’t even always depression. A fast-growing body of research is changing the very definition of maternal mental illness, showing that it is more common and varied than previously thought." ‘Thinking of Ways to Harm Her’ and "After Baby, an Unraveling". [more inside]
Post-operative Check: "It's okay that you don't remember me. My name is Shara, and I'm part of the surgical team. I'm checking to see how you're doing after your surgery. Do you know where you are right now?" [more inside]
Scientists Progress in Quest to Grow Muscle Tissue in Labs - "The researchers are now working on optimizing the growth of human muscle tissue, including finding a way to get blood flow to the tissue, the best source of cells and the best growing medium for the cells."
Jennie Linn McCormack "isn’t the only woman in recent years to be prosecuted for ending her own pregnancy. But her case could change the trajectory of abortion law in the United States": The Rise of DIY Abortions. [more inside]
291 diseases and injuries + 67 risk factors + 1,160 non-fatal complications = 650 million estimates of how we age, sicken, and die
As humans live longer, what ails us isn't necessarily what kills us: five data visualizations of how we age, sicken, and die. Causes of death by age, sex, region, and year. Heat map of leading causes and risks by region. Changes in leading causes and risks between 1990 and 2010. Healthy years lost to disability vs. life expectancy in 1990 and 2010. Uncertainties of causes and risks. From the team for the massive Institute for Health Metrics and Evaluation Global Burden of Diseases, Injuries, and Risk Factors Study 2010. [more inside]
A chronic public health disaster. Complex trauma and toxic stress puts children into a state of reflexive fight, flight, or freeze responses to a perpetually threatening world. The traditional authoritative response only serves to reinforce those behaviours and, perhaps worse, has long-term health consequences:
With an ACE score of 4 or more, things start getting serious. The likelihood of chronic pulmonary lung disease increases 390 percent; hepatitis, 240 percent; depression 460 percent; suicide, 1,220 percent.One doctor describes it as “a chronic public health disaster”. Remediating this problem is going to require listening, kindness, and parachutes.
Jane Pratt (formerly of Sassy Magazine and her eponymous Jane,) launched a website for women: xojane, earlier this year. Last week the site's Health and Beauty Director wrote a blog post explaining that she never uses condoms, birth control pills, or other contraception (for fear of becoming fat) and instead relies on the emergency contraceptive Plan B to prevent pregnancy. And a segment of the internet exploded. (Her responses to some of the comments seem a bit clueless for someone with her title.) Critics have noted that the post was filled with "ignorant" "inaccuracies and misconceptions" about womens' health, sex, Plan B and other forms of birth control. [more inside]
Foldit - Crystal structure of a monomeric retroviral protease solved by protein folding game players
Gamers solve molecular puzzle that baffled scientists. The structure of a protein causing AIDS in rhesus monkeys had not been discovered in 15 years of attempts. Players of a videogame did it in ten days. Foldit, the game in question. Abstract. Previously, previously.
Hesperian is a non-profit publisher of books and newsletters for community-based health care, mostly aimed at the third world. Their first book, Where There Is No Doctor, A Village Health Handbook, has been translated into 88 languages and is one of the most widely used training and work manuals for community health care in the world. They have now made 20 of their publications available for free download, many of which can now also be browsed online through their website using an "Ebrary" in-browser interface. [more inside]
The Triumph of New-Age Medicine "Medicine has long decried acupuncture, homeopathy, and the like as dangerous nonsense that preys on the gullible. Again and again, carefully controlled studies have shown alternative medicine to work no better than a placebo. But now many doctors admit that alternative medicine often seems to do a better job of making patients well, and at a much lower cost, than mainstream care—and they’re trying to learn from it." [more inside]
Using a 3-D petri dish, Researchers at Brown University and Women & Infants Hospital of Rhode Island have built a completely functional artificial human ovary that will allow doctors to harvest immature human egg cells (oocytes) and grow them into mature, ready-to-be-fertilized human eggs outside the body. (In vitro) The advance could eventually help preserve fertility for women facing chemotherapy or other medical treatments that may be destructive to ovarian folliculogenesis. Press Release. Article link. (paywall) [more inside]
Possibly NSFW: The human penis, its life cycle, size and myths about it, why it looks like that, what can go wrong with it and last but not least, the anatomy.
Scientists Repurpose Adult Cells - "Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a variety of illnesses and sidestep the political and ethical quagmires associated with embryonic stem cell research." [nature abstract, nature writeup, audio announcement]
West Nile virus and Avian influenza and Chronic wasting disease, oh, my! (and Monkeypox...) Outbreaks of disease in populations of wild and domestic animals, having such a heavy impact on human health, has led the United States Geological Survey and the University of Wisconson to develop a way to track news of disease outbreaks around the planet: The Global Wildlife Disease News Map.
Dictionary of Disorder - shaping the DSM
Obesity and Diabetes - another free supplement by Nature
Psychiatry by Prescription - Do psychotropic drugs blur the boundaries between illness and health?
Thou shalt not make scientific progress. "Medical research is poised to make a quantum leap that will benefit sufferers from Alzheimer's, Parkinson's, muscular dystrophy, diabetes and other diseases. But George W. Bush's religious convictions stand in its way."