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Blasdelb (4)

"It took more time than it should have for them to be put in isolation"

In the past weeks, there have been 20 confirmed cases of the measles in New York. After being virtually "eradicated" in the United States in 2000, 2013 saw 189 cases reported. The most recent outbreak seems to have spread due to "failure of medical workers to recognize the disease quickly enough and to quarantine patients so they would not infect others." And via Slate: "I’m a Pediatrician. Should I Treat All Kids, or Just the Vaccinated Ones?"
posted by roomthreeseventeen on Mar 20, 2014 - 232 comments

11 Reasons to Be Optimistic in 2014

It's not all bad news. People are living longer, we're winning the fight against malaria, worldwide poverty is down, and eight more reasons for hope in the coming year.
posted by gottabefunky on Dec 30, 2013 - 127 comments

Vaccines: How Do They Work?

Noted anti-vaccination activist Jenny McCarthy is going to replace Elizabeth Hasselbeck as The View's newest panelist. So, now, she can take her anti-vaccine roadshow to the masses. Even though she admitted that her son never had autism. A Slate columnist is even trying to petition The View to not hire Ms. McCarthy.
posted by reenum on Jul 15, 2013 - 195 comments

Viruses That Make Zombies and Vaccines

This week the FDA announced that they were approving a new kind of flu vaccine. Nestled in the articles was an odd fact: unlike traditional flu vaccines, the new kind, called Flublok, is produced by the cells of insects. This is the kind of detail that you might skim over without giving it a thought. If you did pause to ponder, you might be puzzled: how could insects possibly make a vaccine against viruses that infect humans? The answer may surprise you. To make vaccines, scientists are tapping into a battle between viruses and insects that’s raging in forests and fields and backyards all around us. It’s an important lesson in how to find new ideas in biotechnology: first, leave biologists free to explore the weirdest corners of nature they can find. [more inside]
posted by Blasdelb on Jan 19, 2013 - 7 comments

Virulence-transmission trade-offs and population divergence in virulence

"Why do parasites harm their hosts? Conventional wisdom holds that because parasites depend on their hosts for survival and transmission, they should evolve to become benign, yet many parasites cause harm. Theory predicts that parasites could evolve virulence (i.e., parasite-induced reductions in host fitness) by balancing the transmission benefits of parasite replication with the costs of host death. This idea has led researchers to predict how human interventions—such as vaccines—may alter virulence evolution, yet empirical support is critically lacking." Two papers demonstrate empirical evidence for related models predicting the origin of virulence: [more inside]
posted by Blasdelb on Oct 21, 2012 - 23 comments

India declared free of Polio for one year

Recently, the World Health Organisation anounced that India has officially broken the chain of Polio transmission, with no new cases reported in the last year. Following independent checks of the reporting laboratories, Indian Health Minister announced that WHO "has taken India's name off the list of polio endemic countries". [more inside]
posted by metaBugs on Feb 26, 2012 - 21 comments

Not immune to criticism

Vaccinate, or begone. Some pediatricians are refusing to see children whose parents refuse to allow vaccination.
posted by bitmage on Feb 15, 2012 - 344 comments

"An extremely significant milestone".

Researchers from the University of Western Ontario have announced the launch of human clinical trials of a preventative HIV vaccine.
posted by mhoye on Dec 21, 2011 - 23 comments

Vaccines: The Greater Good?

"if you don’t have the science and evidence to back up your point of view, in order to persuade someone, make a movie." Science-Based Medicine reviews "rational and scientific" vaccine skeptic film, The Greater Good.
posted by the young rope-rider on Nov 15, 2011 - 34 comments

Biting back at Malaria...

A new malaria vaccine has been shown effective in large-scale field trials. After decades of disappointment, researchers think they're finally on track to unleash the first practical vaccine against malaria, one of mankind's ancient scourges. In the world's first large field trial of an experimental malaria vaccine, several thousand young children who got three doses had about 55 percent less risk of getting the disease over a year than those who got a control vaccine against rabies or meningitis. [more inside]
posted by BobbyVan on Oct 18, 2011 - 21 comments

The Girl Who Survived Rabies

Recently, 8-year-old Precious Reynolds became the sixth person in history to survive rabies without a vaccine. A few years back, Extraordinary People put out a documentary (1 2 3) on the first person to beat the only viral disease that hides itself completely from one's immune system.
posted by gman on Jun 14, 2011 - 56 comments

The end of the end of polio?

With the help of Bill Gates, the World's efforts to eradicate polio (PDF) have over the last few years gained a great deal of new hope (TED) [more inside]
posted by Blasdelb on May 27, 2011 - 66 comments

Progress in the understanding of AIDS immunology

In a recent paper published in Nature Hansen et al. show the efficacy of their unusual vaccine strategy against SIVMAC239 in rhesus macaques. While the goal is not necessarily to produce a human vaccine against HIV using this exact strategy, this paper is now reigniting the debate over the progression of HIV infections and the mechanism(s) by which the virus skirts the human immune system.
posted by Blasdelb on May 13, 2011 - 4 comments

BMJ accuses researcher who claimed link between vaccines and autism of fraud

The British Medical Journal has called Andrew Wakefield, the lead author of the study that initially claimed a link between the MMR vaccine and autism, a fraud. Investigative journalist Brian Deer went through the original medical records of the children included in the study and found that, amongst other things, some of them didn't have autism. Language this strong in a journal like this is pretty unusual, especially given the UK's libel laws. The Lancet retracted the original paper (PDF) last year due to concerns about breaches of research ethics (previously on Metafilter), but the BMJ is claiming deliberate manipulation and misrepresentation of data for financial gain.
posted by une_heure_pleine on Jan 7, 2011 - 120 comments

Advance Market Commitments

Inducement Prizes -- Best known for the Ansari X Prize, the DARPA Grand Challenge and the Clay Mathematics Millennium Problems, inducement prizes have a long history, but their recent successes have led to increased government interest, viz. challenge.gov, and resulted in the development of vaccines, thanks in large part to the work of Michael Kremer.* [more inside]
posted by kliuless on Jan 6, 2011 - 8 comments

Tragedy Transposed, The Sounds of HIV

There is no question that HIV is an ugly virus in terms of human health. Each year, it infects some 2.7 million additional people and leads to some two million deaths from AIDS. But a new album manages to locate some sonic beauty deep in its genome. Sounds of HIV (Azica Records) by composer Alexandra Pajak explores the patterns of the virus's nucleotides as well as the amino acids transcribed by HIV, playing through these biologic signatures in 17 tracks. [more inside]
posted by infinite intimation on Nov 12, 2010 - 20 comments

More lethal than war no more?

It's been suggested that the humble mosquito is responsible for more deaths than all the wars combined. Scientists working at the Planck institute are hoping to change this by using the mosquitoes themselves as a way to administer a malaria vaccine. [more inside]
posted by quin on Oct 22, 2010 - 13 comments

"...and Wakefield was contracted to conduct scientific research for him."

The Facts In The Case Of Dr. Andrew Wakefield. A fifteen page comic about the MMR vaccination controversy. Previously.
posted by ignignokt on May 26, 2010 - 87 comments

"Thomas Edison has said 'The doctor of the future will give no medicines.' "

Desiree Jennings is a 25-year old marketing manager (and Redskins "Ambassador cheerleader") who claims that in August she received a seasonal flu vaccine at a grocery store that caused a never-before-seen dystonia. While saturating media outlets and drawing the support of celebrity anti-vaccinationists, she shunned the doctors who treated her at Johns Hopkins University who (along with other neurologists who have seen footage of her) judged that she was suffering from a psychogenic disorder. [more inside]
posted by inoculatedcities on Nov 8, 2009 - 103 comments

Does the (Flu) Vaccine Matter?

In Does the Vaccine Matter?, Shannon Brownlee and Jeanne Lenzer discuss the history of vaccines and explore why "some flu experts are challenging the medical orthodoxy and arguing that for those most in need of protection, flu shots and antiviral drugs may provide little to none." In a related story (which condenses and provides a point-by-point summary of the original (with obvious bias)): "Flu vaccines revealed as the greatest quackery ever pushed in the history of medicine."
posted by torquemaniac on Oct 14, 2009 - 90 comments

HIV vaccine shows promise

A new HIV vaccine is showing promising results, reducing the risk of contracting the virus by 32 percent. While further tests are still needed, the vaccine is a combination failed HIV vaccines AIDSVAX and ALVAC, based on the Canary Pox virus. The study itself faced criticism from the outset.
posted by borkencode on Sep 24, 2009 - 41 comments

A Modest Proposal

Depending on which side of the Irish Sea you live, the HPV jab is either a killer that shouldn't be given to young women or it's a necessary and life saving vaccination. Layscience.net exposes the disturbingly awful cynicism of The Daily Mail. (via badscience.net)
posted by seanyboy on Apr 20, 2009 - 28 comments

Science FTW

A German researcher accidentally jabbed her finger with a hypodermic loaded with the deadly Ebola virus. 48 hours later, she was injected with an untested, experimental vaccine, developed by an international team of virologists and biologists. Though she may never have been infected, she was certainly in danger; in 2004, a similar incident caused the death of a Russian scientist at a former Soviet biological weapons lab.
posted by permafrost on Mar 29, 2009 - 39 comments

If after 20 years you don't succeed.

Maybe it's time to give up. Last year's failed clinical trial for Merck's HIV vaccine (which once appeared so promising) led many to claim that AIDS vaccine research is in crisis. According to an unprecedented poll conducted by The Independent most scientists involved in AIDS research believe that a vaccine against HIV is further away than ever and some have admitted that effective immunisation against the virus may never be possible. [more inside]
posted by three blind mice on Apr 24, 2008 - 59 comments

Settlement in case of child who developed autistic symptoms after being vaccinated

Hannah Poling is a nine year old girl with mild to moderate symptoms of autism, which developed three months after she received vaccinations. The Department of Health and Human Services announced that her family will receive a settlement from the vaccine compensation fund. Autism activists are encouraged, but the DHHS officials insist they are not admitting a link between autism and vaccines and maintain that for most, vaccines are safe. Rather, they say, the series of vaccines Hannah received exacerbated an underlying mitochondrial condition, causing the symptoms of autism. [more inside]
posted by arnicae on Mar 7, 2008 - 125 comments

Cocaine vaccine

Cocaine vaccine in the works [more inside]
posted by selfmedicating on Jan 5, 2008 - 44 comments

The end of influenza?

The end of influenza? New british vaccine may prevent ALL types of flu, savings thousands of lives (and sick days) each year.
posted by Kickstart70 on Dec 28, 2006 - 26 comments

If they'd had this website there'd have only been 6 dwarves

Both Find a Flu Shot and Flu Clinic Locator will let you punch in a date & zip code and find a bunch of locations near you in the U.S. selling the vaccine. For the first time in three years there's plenty to go around. The CDC estimates that everyone who might want one will be able to get one. And you probably want one. According to wikipedia "36,000 people per year in the United States die from influenza, and 114,000 per year are admitted to a hospital as a result of influenza. According to estimates by the World Health Organization, between 250,000 and 500,000 die from influenza infection each year worldwide." That's 5 to 10 times as many civilian casualties as the Iraq conflict in 1/3 the time. [more inside]
posted by phearlez on Oct 5, 2006 - 46 comments

new hope for a vaccine or cure?

AIDS really did come from chimps in the 1950s --..."We're 25 years into this pandemic," Hahn said. "We don't have a cure. We don't have a vaccine. But we know where it came from. At least we can make a check mark on one of those." ... ...Identifying the source of the HIV pandemic is more than filling in a missing link in the disease's progression. ...
posted by amberglow on May 25, 2006 - 25 comments

You know what crazy is? Crazy is majority rules. Take germs for example.

It is estimated that due to an infected polio vaccine, 10 million to 30 million people in the United States from 1955 through early 1963 were inadvertently exposed to live Simian Virus #40, a pathogen linked to various cancers. If it happened before, maybe it happened again. Perhaps AIDS was just another accidental contamination originating in an American lab - this time a hepatitis vaccine gone wrong. Why assume conspiracy Dr Cantwell?
posted by missbossy on Apr 24, 2006 - 74 comments

Ricin Vaccine Saf

Human trials show ricin vaccine is safe. For those that don't know ricin is a very potent poison that can be made from castor beans. Details of medical effects are available on Emedicine. Ricin was famously used in the murder of Georgi Markov. Research was done at UT Southwestern Medical Center in Dallas, TX.
posted by reverenddrjice on Feb 1, 2006 - 13 comments

Better dead than bed(ded)

Newsfilter: Several pharmaceutical companies are developing vaccines against strains of the human papilloma virus that cause cervical cancer. Some folks think these shots should be required for all kids entering puberty. Others are afraid that teens given the vaccination would view it as a free pass for premarital sex.
posted by brundlefly on Nov 1, 2005 - 77 comments

Nicotine Vaccine Shows Promise

Nicotine Vaccine Shows Promise. Smokers may have some help kicking the habit from an inoculation being tested by several companies.
posted by sjvilla79 on May 15, 2005 - 18 comments

"Preparing for the next pandemic."

1.7 million deaths in the U.S. and 180-360 million dead globally. That's the estimate of the impact of the next influenza pandemic from Michael Osterholm, published in today's New England Journal of Medicine. He warns that almost every public health response to the inevitable emergence of pandemic influenza A strain is unplanned or inadequate: A vaccine would take minimum six months (and millions of fertilized chicken eggs); there are no plans to setup and staff the temporary isolation wards or replace dead health-care workers; nor are there detailed plans for handling the number of dead bodies. Given the deeply interconnected nature of the global economy a pandemic would be impossible to stop and wreak havoc in every nation. "Frankly the crisis could for all we know have started last night in some village in Southeast Asia," said Dr. Paul Gully, Canada's deputy chief public health officer. "We don't have any time to waste and even if we did have some time, the kinds of things we need to do will take years. Right now, the best we can do is try to survive it. We need a Manhattan Project yesterday."
posted by docgonzo on May 5, 2005 - 75 comments

flu

Another year, another flu vaccine shortage. Perhaps it just the first salvo of 2004's media Flu Frenzy! I think this winter I will retire the the TV, forget about my pharma portfolio and instead light a fire, swig some hot lemon and honey tea, and spice up my life.
posted by thedailygrowl on Oct 5, 2004 - 6 comments

Malaria vaccine casues permanent brain damage

In the can-anything-else-go-wrong file, US Troops suffer from permanent brain damage after being administered malaria treatment. For as big a logistical challenge a war might be, and technological advances in mass support systems, you'd think the joint-forces would do a better job?
posted by omidius on May 27, 2004 - 11 comments

Mutating Strands of HIV

First Documented Case of HIV hybridization in a human being was presented at the International AIDS Society conference in Paris. In this case, genetic tests on a superinfected woman showed that the two strains she was infected with swapped genetic material, creating a new hybrid strain of HIV. The actual effects are not yet clear, but this could pose a serious problem for researchers trying to create a vaccine.
posted by Irontom on Jul 16, 2003 - 8 comments

tick, tick, tick ...

They're ugly. I mean small and really ugly! And they don't do us any favors at all. We can hold each other's hands, and share support. Our fight against them may lead to knowledge in other battles, but I think its time to go on the offensive. Its time to defang the beastie. (Maybe I should have posted this at Warfilter instead?)
posted by Wulfgar! on May 20, 2003 - 20 comments

Who wants some toxins with their cold viruses?

A scientist discovers that scorpions make two types of venoms. Cool. But he made the discovery while attempting to find a toxin that he wants to put into a common cold virus, in order to kill insects that catch the cold? Shouldn't we be worried about this?
posted by titboy on Jan 21, 2003 - 16 comments

Smallpox Vaccination?

Smallpox Vaccination? The New England Journal of Medicine made available today an early release of articles from their planned January 30, 2003 issue, designed "to help inform the current national debate about smallpox vaccination" [more inside....articles unfortunately available only in PDF....]
posted by fold_and_mutilate on Dec 20, 2002 - 31 comments

Feline Immunodeficiency Virus & Animal Lentiviruses

But what about the kitties? Feline Immunodeficiency Virus. FIV has been recognized as a syndrome since 1986, and as with AIDS, has been found in stored blood samples dating back to the 60s. Unlike HIV, however, for FIV there's a vaccine. Not that everyone is excited about it.

Originally, this was to be a post intended to provide something lighter until this appeared:

In addition, over 25 large cat species including, cheetahs, lions, and panthers have their own strain of the virus. Despite similarity among these viruses, transmission among species has never been documented. Scientists think that FIV is an old virus and may be the grandfather of all immunodeficiency viruses. Comparison of its' genetic code point to a virus that is millions of years old.

Googling led to several topics.
posted by y2karl on Dec 1, 2002 - 3 comments

Living With Aids

Steve Schalchlin, a singer-songwriter, writes about living with AIDS in his online journal. Students at Marshall High School put themselves in the shoes of an HIV-positive girl, in the project My name is Kerry and I have AIDS (Now I'm dead!). Journalist Eric Foss keeps a diary about his visits to AIDS victims in Zambia, with pictures, video and interview transcripts. Adam Solomon writes at length about training for and participating in several AIDS rides for vaccine and cure charities. Five years old, but still affecting, there's AIDS worker Paul Gallotta's AIDS diary. Supporting group efforts of AIDS victims and other interested parties is the journal Being Alive. There's a vast catalog of compelling first-person perspective at HIV/AIDS Positive Stories, at Avert.org, and at Breaking the Silence... Rompiendo El Silencio from the AIDS Project Los Angeles.
posted by Mo Nickels on Dec 1, 2002 - 0 comments

Early tests show 100% success for cervical cancer vaccine

Early tests show 100% success for cervical cancer vaccine "It appears to be the real thing,'' said Dr. Christopher Crum, a pathologist at Brigham and Women's Hospital in Boston. "You're looking at some very compelling evidence that this vaccine will prevent cervical cancer.''
posted by nickmark on Nov 20, 2002 - 12 comments

The NIH is abandoning phase III trials of a possible hiv vaccine due to "technical reasons" the trial will continue in thailand. On a happier note there are currently more than 90 other hiv vaccines in other stages of trials. What do people think are the chances the pharmaceuticals will decide chronic disease management is more profitable, and actually do something to make this a more likely outcome?
posted by rhyax on Feb 25, 2002 - 21 comments

We can all breathe a little easier now,

We can all breathe a little easier now, but it comes at a hefty price - $428 million. That's a boatload of money for a security blanket we may not even need. It's times like this, though, that make me happy (not necessarily proud) to be an American. What do you think?
posted by catatonic on Nov 28, 2001 - 11 comments

Defense Department's Anthrax Site.

Defense Department's Anthrax Site. Wierd. Wierd. Wierd. Click on FLASH version.
posted by xammerboy on Oct 8, 2001 - 23 comments

Malaria is one of the planet's deadliest diseases and one of the leading causes of sickness and death in the developing world. According to the World Health Organization there are 300 to 500 million clinical cases of malaria each year resulting in 1.5 to 2.7 million deaths. Malaria is a public health problem today in more than 90 countries, inhabited by a total of some 2 400 million people -- 40% of the world's population. It is also notoriously difficult to combat because of the parasite's ability to easily evade the body's immune system. Nature Update has an article on the possibilities of designing a malarial vaccine which stimulates the immune response and has the potential of protecting people from all strains of the disease.
posted by lagado on Nov 2, 2000 - 0 comments

http://www.guardianunlimited.co.uk/international/story/0,3604,372067,00.html

http://www.guardianunlimited.co.uk/international/story/0,3604,372067,00.html Thousands of South American indians were infected with measles, killing hundreds, in order to for US scientists to study the effects on primitive societies of natural selection.
posted by hobbes on Sep 22, 2000 - 5 comments

Immortality Protein May Offer Cancer Vaccine.

Immortality Protein May Offer Cancer Vaccine. You know, I'm glad they're making progress, but once the 'cure' is found, I can't daydream about being this smart, intelligent doctor, (something right out of a soap), that creates the cure for cancer, and woos all the la-a-dies... then again there is always being that evil-twin and start cloning, with that, you won't need to wooo anyone, they're your toys! mwahahaha!
posted by tiaka on Aug 30, 2000 - 0 comments

Vaccine linked to Autism?

Vaccine linked to Autism? Something every parent should know. I don't know if it's true or not, I mean it's not proven, but it is kind of scary.
posted by premiumpolar on Mar 6, 2000 - 0 comments

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