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Psychotropic medication efficacy and publication bias

Antipsychotics: "The magnitude of publication bias found for antipsychotics was less than that found previously for antidepressants, possibly because antipsychotics demonstrate superiority to placebo more consistently."
Antidepressants: "We found a bias toward the publication of positive results. Not only were positive results more likely to be published, but studies that were not positive, in our opinion, were often published in a way that conveyed a positive outcome. [...] Using both approaches, we found that the efficacy of this drug class is less than would be gleaned from an examination of the published literature alone. According to the published literature, the results of nearly all of the trials of antidepressants were positive. In contrast, FDA analysis of the trial data showed that roughly half of the trials had positive results." Previously [more inside]
posted by OmieWise on Apr 3, 2012 - 34 comments

Falling STAR*D?

Falling STAR*D?: It is common practice for psychiatrists to switch depressive patients between different antidepressants if their current drug does not evince a symptomatic response. Despite clinical wisdom supporting this, little empirical, controlled evidence exists to direct “switching” protocols (e.g. if a patient with Z characteristics is on drug X, is it usually better to switch to drug A, B, or C? Will switching help at all?) in the psychopharmacological treatment of depression. The NIMH-funded STAR*D (Sequenced Alternatives to Relieve Depression) study aimed to address these questions of treatment direction in a very large (n>4000), “real-world” sample using a multi-phase treatment plan with different drugs (and cognitive therapy) at every step to maximize chances of eventual remission. Overall, the NIMH reported that about 67% of patients eventually achieved remission, with few differences in effectiveness between different types of treatment at each step. However, researchers and commentators have raised concerns regarding inconsistent reporting of outcomes, after-the-fact changes in study design and analysis, and other issues that may have inflated, partially invalidated, or misrepresented widely reported treatment outcomes. These inequities may also have implications for the secondary moderator analyses (i.e. does trait A predict switching to X or Y is better?) that were a major reason for the study. [more inside]
posted by Keter on Jan 14, 2012 - 12 comments

Placebos

Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why.
posted by homunculus on Aug 25, 2009 - 106 comments

Coming of Age on Antidepressants

Who Are We? Coming of Age on Antidepressants. [Via Mind Hacks.] [more inside]
posted by homunculus on Apr 16, 2008 - 49 comments

Anti-depressants, Serotonin and Depression

"Researchers found that failing to publish negative findings inflated the reported effectiveness of all 12 of the antidepressants studied." See also: Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature. [more inside]
posted by OmieWise on Jan 17, 2008 - 137 comments

Seven Interview with Foster Children

I took my video camera to a Foster Care Alumni meeting and asked seven foster kids to tell me about there experiences in Child Protective Services while wards of the state: Tristen, Andrew, Kyle, Aisha, Elnita, Ashley, Joshua. [more inside]
posted by chunking express on Dec 29, 2007 - 22 comments

Ricky Williams on 'Oprah'

Talking back to Prozac. Review article in The New York Review of Books, covering some issues concerning the diagnosis and treatment of depression.
posted by hydatius on Nov 21, 2007 - 57 comments

Anti-depressants increase suicide risk in young adults, FDA warns

Anti-depressants increase suicide risk in young adults, FDA warns. "When results are analyzed by age, it becomes clear that there is an elevated risk for suicidality and suicidal behavior among adults younger than 25 years of age that approaches that seen in the pediatric population." More here and here. This follows the FDA finding that anti-depressants increased the risk of suicide in young children. The FDA now requires manufacturers of anti-depressants to include warnings, and plans to meet on Dec 13 to discuss the findings further.
posted by shivohum on Dec 12, 2006 - 42 comments

Zoloft Found Safe, Effective in Children

Zoloft Found Safe, Effective in Children The study was funded by Pfizer Inc., which makes Zoloft. Visit The International Coalition For Drug Awareness to find out what SSRI Meds can really do to your kids...
posted by Wicker on Aug 26, 2003 - 53 comments

And they work how exactly?

Anxious? Depressed? - you need more brain cells. Just take one of these twice a day. New research shows that antidepressants may not work as we thought at all, rather they actually stimulate growth of cells in the hippocampus area of the brain. This may all be for the good - but it seems strange that we release millions of happy pills and market them as safe without knowing for sure what they do. Perhaps its the money talking.
posted by grahamwell on Aug 9, 2003 - 75 comments

Hmm. Why am I not surprised?

Hmm. Why am I not surprised? Muddling with your serotonin in such a drastic way has always struck me as an overreaction to depression. Let's be honest. In a world jam-packed with aggressive apes who deny that they are apes, a little depression is a healthy response. Taking a serotonin re-uptake inhibitor just because you feel blue is like taking 10000 micrograms of Acid because you like the Harry Potter books.
posted by Ezrael on Jun 6, 2000 - 30 comments

Speaking of Prozac...

Speaking of Prozac... Did Prozac and Ritalin cause the Columbine disaster? Are these drugs causing kids to kill? The people of "A White Rose" seem to think so. You be the judge.
posted by SuperGoat on Mar 22, 2000 - 3 comments

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