What pushes scientists to lie? The disturbing but familiar story of Haruko Obokata. The spectacular fall of the Japanese scientist who claimed to have triggered stem cell abilities in regular body cells is not uncommon in the scientific community. The culprit: carelessness and hubris in the drive to make a historic discovery.
Scientists Progress in Quest to Grow Muscle Tissue in Labs - "The researchers are now working on optimizing the growth of human muscle tissue, including finding a way to get blood flow to the tissue, the best source of cells and the best growing medium for the cells."
Using a 3-D petri dish, Researchers at Brown University and Women & Infants Hospital of Rhode Island have built a completely functional artificial human ovary that will allow doctors to harvest immature human egg cells (oocytes) and grow them into mature, ready-to-be-fertilized human eggs outside the body. (In vitro) The advance could eventually help preserve fertility for women facing chemotherapy or other medical treatments that may be destructive to ovarian folliculogenesis. Press Release. Article link. (paywall) [more inside]
We may soon be able to clone Neanderthals. But should we? An essay from Archaeology Magazine examines the ethical, scientific and legal ramifications. (Via Heather Pringle's Time Machine blog, where essay author Zach Zorich posted a reply and elicited a response.) [more inside]
Scientists Repurpose Adult Cells - "Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a variety of illnesses and sidestep the political and ethical quagmires associated with embryonic stem cell research." [nature abstract, nature writeup, audio announcement]
Scientists report a breakthrough in stem cell production: Stem cells created from ALS patient and used to make neurons. [Via]
More cuckoo than cuckoos: mate two salmon, get a... trout! Just give the parents a sperm transplant. And the sperm stem cells work in females too:
...Injecting the male cells into female salmon sometimes worked, too, prompting five female salmon to ovulate trout eggs.... The stem cells were still primitive enough to switch gears from sperm-producers to egg-producers when they wound up inside female organs....
Canadian scientists heal spinal injuries with stem cells from skin (in rats). "Over the course of their research, the team found that skin-derived stem cells share characteristics with embryonic neural stem cells, which generate the nervous system. ... After 12 weeks, the rats were able to walk better, with more co-ordination." [more inside]
Simple switch turns cells embryonic. "Researchers have finally hit the jackpot: Embryo-free embryonic stem-cells!"
A British research team led by the world's leading heart surgeon has grown part of a human heart from stem cells for the first time.
For the first time, researchers have used adult bone marrow stem cells to regenerate healthy human liver tissue, according to a study published in the April issue of the journal Radiology.
Sea Squirt Regrows Entire Body from One Blood Vessel. Most famous as the creature that settles down and eats its own brain (though that is not exactly correct), it appears the humble sea squirt has spectacular regenerative abilities as well, thanks to regeneration niches packed with stem cells. All glory to the sea squirt!
"Molecular scientists . . . have developed a new procedure for the differentiation of human embryonic stem cells, with which they have created the first transplantable source of lung epithelial cells."
Nature has a somewhat technical but free supplement on stem cells (alongwith a podcast and related blog).
The National Academies have finally released suggested guidelines for research with embryonic stem cells and chimeras.
Thou shalt not make scientific progress. "Medical research is poised to make a quantum leap that will benefit sufferers from Alzheimer's, Parkinson's, muscular dystrophy, diabetes and other diseases. But George W. Bush's religious convictions stand in its way."