Diagnosed with terminal cancer two years ago, and given only months to live, Sam Simon is still alive and still racing to spend the fortune he made as co-creator of The Simpsons on causes he loves, whether he is rescuing grizzly bears (and chinchillas and elephants) or funding vegan food banks. Sam Simon and philanthropy previously on Metafilter
X inactivation is a type of gene dosage compensation. In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development. Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21. In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.
Here is a helpful eleven minute description of what it is and why it's important by Etsuko Uno and metafilter's own Drew Berry in a fucking gorgeous Goodsell-esque 3D animation.[more inside]
Aidan is a 5 year old boy who was recently diagnosed with leukemia. Aiden really loves monsters, both dressing up as them, and drawing them. His family has is selling his artwork to help with medical expenses. [more inside]
A pinhole photography buff documents his second cancer experience. The straightforward narrative is very striking, and the photos, while sometimes off the strict topic, build a picture of a real person.
Breast Cast Art. (NSFW? I don't know, your call.) Modart's Keep a Breast 2002 is currently auctioning off these artistic busts to benefit The Breast Cancer Fund.