Vaults are large, barrel shaped protein complexes. Found in most eukaryotic cells, their exact function is currently unknown. [more inside]
"Scientists reset human stem cells to earliest developmental state" The paper, published in Cell, is available under a CC-3.0 license. [See: earlier Mefi post] [more inside]
The Hidden Life Of the Cell (57:24) There is a battle playing out inside your body right now. It started billions of years ago and it is still being fought in every one of us every minute of every day. It is the story of a viral infection - the battle for the cell. This film reveals the exquisite machinery of the human cell system from within the inner world of the cell itself - from the frenetic membrane surface that acts as a security system for everything passing in and out of the cell, the dynamic highways that transport cargo across the cell and the remarkable turbines that power the whole cellular world to the amazing nucleus housing DNA and the construction of thousands of different proteins all with unique tasks. The virus intends to commandeer this system to one selfish end: to make more viruses. And they will stop at nothing to achieve their goal. Exploring the very latest ideas about the evolution of life on earth and the bio-chemical processes at the heart of every one of us, and revealing a world smaller than it is possible to comprehend, in a story large enough to fill the biggest imaginations.
You may be familiar with molecular movies from my two previous megaposts collecting them, but this extended documentary uses original animation that is collected into a coherent educational narrative and is just so fucking gorgeous. Enjoy.[more inside]
Light makes a comeback. “New technologies — more sophisticated imaging techniques, fluorescent molecules that act as beacons of light in the cell, and the computing power to gather and stitch together multiple images and create videos from high-powered microscopes — make it possible to harness one of light’s key advantages: gentleness. Unlike higher-resolution techniques, light microscopes can image biological structures without killing them or chemically fixing them. At Harvard, the resurgence of light microscopy is making it possible to see structures and events that have never before been seen in the context of living cells and organisms.” Also don't miss the video samples of “in vivo” imagining.
"We have [a substance] that extends the life of every species it's given to. We're 50 years ahead of where I thought we would be 10 years ago." While Harvard Medical School rules prevent David Sinclair from recommending product, "I know a number of scientists who think [it] is their best shot. Others satisfy themselves with a glass of red wine," which contains the compound. Too good to be true?