In 1984, the same year that Stop Making Sense was released, another meticulously crafted Talking Heads concert movie made its debut as well. Once in a Lifetime
is a 69-minute piece of experimental television (originally broadcast on England's Channel 4) that Talking Heads fans (as well as those interested in mid-80s video montage stylings) will surely want to check out.
posted by flapjax at midnite
on Nov 13, 2013 -
X inactivation is a type of gene dosage compensation. In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development. Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21. In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.
Here is a helpful eleven minute description of what it is and why it's important by Etsuko Uno and metafilter's own Drew Berry in a fucking gorgeous Goodsell-esque 3D animation. [more inside]
posted by Blasdelb
on Sep 14, 2013 -
Legendary lyricist Hal David
, most famously partnered with composer Burt Bacharach, and countless pop performers ranging from Dionne Warwick to Tom Jones to The Carpenters and beyond, has died
at age 91.
posted by 2N2222
on Sep 1, 2012 -
"Blood and Fire"
is an episode written by David Gerrold for possible use on Star Trek: The Next Generation. The script was commissioned and written, but never actually filmed because certain studio executives had a negative reaction to its positive depiction of an openly gay couple. It was eventually adapted by Gerrold into a standalone novel
With Gerrold's permission, Carlos Pedraza rewrote Blood and Fire for the fan series Star Trek: New Voyages
. Gerrold did a final draft polish and also directed the episode.
The entire two part episode is available on You Tube: Part 1
, Part 2 [more inside]
posted by wittgenstein
on Jun 11, 2012 -
Reading Markson Reading:
‘Exploring the mind, method and masterpieces of David Markson through the marginalia found on the pages of the books in his personal library.’ (previously: 1
posted by misteraitch
on Apr 20, 2012 -
"their purposes are entirely opaque to me, as are the purposes of so many others" was the first (eerily self-descriptive) 'card' I got in Strategies
, a bot in the tradition of Brian Eno's Oblique Strategies
but with most content fed from horse_ebooks.
Although, I think that is a quote from a terrifying Cronenberg student film, Crimes of the Future
. The 'purpose' of this bot, according to the description is "for use when you're lacking inspiration, or make your own game of it."
posted by aretesophist
on Apr 4, 2012 -
In 2008, T: Magazine released a 12-part video series called "T Takes
," (Also on Youtube
) which featured up and coming indie and mainstream actors in short (2 - 3 minute) improvisational roles. A 6-part sequel series Brooklyn '09
was released the following year -- an episodic love story that was not as celebrity oriented. [more inside]
posted by zarq
on Jun 1, 2011 -
David Wu will cut you, with his claws.
Representative David Wu (D-OR) sends out pictures of himself in a tiger costume, his staffers wonder about his mental state; he denies any issues claiming he feels GRRRRREAT!
(scroll down on the MSNBC page for tigery picture goodness). [more inside]
posted by aloiv2
on Feb 23, 2011 -
"Is this thought experiment monstrous?
Would it be monstrous to refer to the 40,000-plus domestic highway deaths we accept each year because the mobility and autonomy of the car are evidently worth that high price?" In 2007 David Foster Wallace invited readers to a series of thought experiments in a short piece. [more inside]
posted by fantodstic
on Sep 12, 2010 -
The president of Penguin Canada has been fired
and is facing a sexual harrassment suit. Oh, and a second woman
has alleged harrassment as well. There's some criticism of Penguin
also for trying to cover up the facts at first. And there's a portrait of the "artist
" as a young man. Sounds like it would make a good book ...
posted by anothermug
on Jun 20, 2010 -
, professor of computer science, painter, neoconservative columnist, and unabomber victim, on rethinking the internet
The structure called a cyberstream or lifestream is better suited to the Internet than a conventional website because it shows information-in-motion, a rushing flow of fresh information instead of a stagnant pool.
posted by DZack
on Apr 11, 2010 -
, beloved caricaturist for several publications, but most notably for the New York Review of Books
last Tuesday at age 83 due to complications of prostate cancer. Since 1963, he contributed over 3,800 caricatures for the magazine, which prominently featured his drawings in promotional material. You can look at over 2,500 of his drawings here
, review his website featuring his painting here
, and see him interviewed here
Toward the end of his life, his vision failed due to macular degeneration and his relationship with the magazine became somewhat strained
. Upon his death, the magazine noted that he was, simply, "the greatest caricaturist of his time." [more inside]
posted by pasici
on Jan 1, 2010 -
David Rees's comic strip Get Your War On
), has been appropriated by Jamba Juice
into an animated Flash video
. Rees, of course, built Get Your War On
using clip art, which makes matters a little trickier. Is Jamba Juice's ad a case of fair use? Or are there enough factors being used here for Rees to have a casus belli? Will we see more advertisements pilfering along these lines?
posted by ed
on Jul 20, 2009 -
To Marty, This bespells doom!
A recent reading in Manhattan at the Strand bookstore by David Sedaris, whose most recent book is “When You Are Engulfed in Flames,” may have offered a glimpse of the future. A man named Marty who had waited in the book-signing line presented his Kindle, on the back of which Mr. Sedaris, in mock horror, wrote, “This bespells doom.” (The signed Kindle was photographed, but its owner’s full name is unknown.)
posted by Fizz
on Jun 16, 2009 -
Last week when I checked my mailbox,
I found that my new neighbour had left me a note stating that he was having a party and to let him know if the noise was too loud.
The problem I have with the note is not that he was having a party and didn't invite me, it was that he selected a vibrant background of balloons, effectively stating that his party was going to be vibrant and possibly have balloons and that I couldn't come. [more inside]
posted by Ljubljana
on Feb 20, 2009 -
This, like many clichés, so lame and unexciting on the surface, actually expresses a great and terrible truth. It is not the least bit coincidental that adults who commit suicide with firearms almost always shoot themselves in: the head. They shoot the terrible master. And the truth is that most of these suicides are actually dead long before they pull the trigger.
And I submit that this is what the real, no bullshit value of your liberal arts education is supposed to be about: how to keep from going through your comfortable, prosperous, respectable adult life dead, unconscious, a slave to your head and to your natural default setting of being uniquely, completely, imperially alone day in and day out. That may sound like hyperbole, or abstract nonsense. Let's get concrete. The plain fact is that you graduating seniors do not yet have any clue what "day in day out" really means. There happen to be whole, large parts of adult American life that nobody talks about in commencement speeches. One such part involves boredom, routine, and petty frustration. The parents and older folks here will know all too well what I'm talking about.
First reported by an anonymous tip to a blog
, the Los Angeles Times
has confirmed that David Foster Wallace has hung himself.
posted by gerryblog
on Sep 13, 2008 -