Last April, motivated by rumors of a Chinese paper published the next month that physically demonstrated the technical feasibility of editing human germline DNA with CRISPR by successfully modifying human embryos, a coalition of well regarded scientists assembled to address this fundamentally new ability and they called for an international summit. It was to be billed as a new Asilomar Conference on Recombinant DNA for a new age in order to lead a new global conversation on questions of whether and how to control human inheritance, which could only be dreamed of 40 years ago. This is a fundamental departure from the non-inheritable gene engineering with CRISPR covered on the blue recently. Thus, from December 1-3, the International Summit on Human Gene Editing, held as a collaborative effort between U.S. National Academy of Sciences and National Academy of Medicine, the Chinese Academy of Sciences, and The Royal Society, met to discuss the future of this technology and has come out with a clear consensus statement. [more inside]
It's well understood that many species of parasitic wasp, when they lay their eggs on host caterpillars, also inject viruses that prevent the host's immune system from attacking the eggs. But it was recently discovered that some of those virus genes, as well as genes from parasitic wasps themselves, have become a part of the genome of some lepidopteran species (even protecting these species from a different type of virus), thus demonstrating horizontal gene transfer between insect species (link to paper).
New GM technique injects mosquitoes with a gene that results in mostly male offspring, eventually leading to a population crash. Previous efforts to tackle the disease, that kills more than 1 million people each year – most of whom are African children – have included bed nets to protect people and insecticides to kill the mosquito species most responsible for the transmission of malaria (Anopheles gambiae). The new technique by a team at Imperial College London involves injecting mosquitoes with a gene that causes the vast majority of their offspring to be male, leading to an eventual dramatic decline in population within six generations as females disappear. “You have a short-term benefit because males don’t bite humans [and transmit malaria],” Andrea Crisanti, one of the authors of the new research, which was published in the journal Nature Communications on Tuesday, told the Guardian. “But in the long term you will eventually eradicate or substantially reduce mosquitoes. This could make a substantial contribution to eradicating malaria, combined with other tools such as insecticides.”
These new mosquitoes are now set to be used in Brazil, having been approved for use by the Brazilian government with a factory for their production now opened.[more inside]
With a database of over 5,000 scientists, from Nobel prize winners to postdocs and PhD students, Sense About Science works in partnership with scientific bodies, research publishers, policy makers, the public and the media, to change public discussions about science and evidence. They make these scientists available for questions from civic organizations and the public looking for scientific advice from experts, campaign for the promotion of scientific principles in public policy, and publish neat guides to understanding science intended for laypeople. [more inside]
In lieu of today's posts on GM foods and meat, Trans Ova Genetics is pharming cows in hopes of creating one capable of adminstering human antibodies.
Isolating the gene responsible for caffeine is expected to lead to decaffeinated beans, and a higher-quality coffee product, all-around... But are they considering other applications? With a bit of gene splicing, anything is possible. Caffeinated oranges, anyone?