What we currently call breast cancer should be thought of as 10 completely separate diseases, according to an international study which has been described as a "landmark". The categories could improve treatment by tailoring drugs for a patient's exact type of breast cancer and help predict survival more accurately. The study in Nature analysed breast cancers from 2,000 women [Abstract] . It will take at least three years for the findings to be used in hospitals. [more inside]
In 2001, we learned the sequence of our genome; now, we have amassed a vast amount of knowledge about what those sequences actually do. Yesterday, the data from the ENCODE project went live. [more inside]
An Icelandic company called deCODE genetics (previously) has found evidence, though not conclusive, that an unknown American woman traveled to Iceland, possibly against her will, as early the year 1000 but not later than 1700. She had offspring in Iceland with natives. 80 of her descendants are still extant in that country. This finding has been announced in a pre-print online publication of the American Journal of Physical Anthropology. The work involved explorations of mitochondrial DNA, which are frequently employed to examine humans' centuries-old lineages. One surprising result is that this lineage does not seem to line up with previously known Native American genetic markers, but the authors believe that the explanation above is "[more] likely" than this common ancestor being European or Asian. (Via Daily Mail.) [more inside]
Followup to this post: A US District Court has ruled that Myriad Genetic's patents on breast cancer genes BRCA1 and BRCA2, which allow them to hold exclusive rights to a widely used genetic test for inherited breast and ovarian cancer susceptibility, are invalid. Genomics Law Report analyzes the ruling in two posts. The decision is likely to be challenged in a legal appeal — but if upheld, it could have huge implications for the biotechnology industry. [more inside]
We may soon be able to clone Neanderthals. But should we? An essay from Archaeology Magazine examines the ethical, scientific and legal ramifications. (Via Heather Pringle's Time Machine blog, where essay author Zach Zorich posted a reply and elicited a response.) [more inside]
Cracking the Cancer Code: We already know that all cancers are caused by DNA mutations acquired during a person's lifetime. But what mutations actually cause cancer? We may be one step closer to finding out. International research teams led by the Cancer Genome Project at the Wellcome Trust Sanger Institute have now mapped the entire genetic code of two of the most common human cancers: lung and skin (malignant melanoma). Their findings have the potential to revolutionize preventative and treatment therapies as well as pave the way for new early detection tests. More. [more inside]
On behalf of medical organizations, universities, & individual patients, pathologists and genetics researchers, the ACLU has filed a lawsuit against Utah-based Myriad Genetics and the US Patent and Trademark Office. Myriad holds the US patents to the BRCA1 and BRCA2 genes, associated with hereditary causes of breast and ovarian cancers. Their patents guarantee the company the right to prevent anyone else from testing or studying those genes, which the ACLU says is unconstitutional and inhibits researchers from finding treatments and cures. [more inside]
My Genome, My Self: Steven Pinker considers what we can expect from personal genomics. Searching for Intelligence in Our Genes: Carl Zimmer looks at the hunt to learn about the role of genes in intelligence.
Neuroscience Gateway - "a comprehensive source for the latest research, news and events in neuroscience and genomics research"
The all-new sneeze-free cat this week joins a distinguished roster of altered organisms, such as glowing green pigs and bunnies, ampicillin-resistant maize and tomato, and even a potato with a bacterial pesticide spliced in. And don't forget OraGenics, the company that wants to infect your teeth with bacteria that won't cause decay - and will crowd out the ones that do. Brave New World, indeed. What's next?