The Animated Genome is a spirited 5-minute film that uses graphics to explain the makeup of your genome and how it affects life and health. It's part of Genome: Unlocking Life's Code, an exhibition at the Smithsonian Institution National Museum of Natural History.
Ubuntu Studio is a Linux distribution focused on creative audiovisual pursuits.
Whitney Music Box [flash] from KrazyDad. You can read about and see examples of John Whitney's work on this extremely ugly website.
Segata Sanshiro! Why show people the graphics and gameplay of your video game, when you can simply beat them into playing it?