The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
Norbert Wiener: The Eccentric Genius Whose Time May Have Finally Come (Again) - "The most direct reason for Wiener's fall to relative obscurity was the breakthrough of a young mathematician and engineer named Claude Shannon." [more inside]
The Nazi Anatomists. "How the corpses of Hitler's victims are still haunting modern science—and American abortion politics."
The Course of Their Lives. While much in medicine has changed over the last century, the defining course of a first year medical student's education is still 'Gross Anatomy.' This is their hands-on tour of a donated cadaver -- an actual human body -- and is an experience which cannot be replicated by computer models. When Milwaukee Journal Sentinel reporter Mark Johnson came up with the idea of following a med school gross anatomy class for a feature story, his editor challenged him to make it different. So he chose to intertwine the students' stories with that of Geraldine 'Nana' Fotsch, a living future donor, as sort of a stand-in for the cadaver. (Via. This four-part series contains descriptions of a human dissection. Some may find it disturbing.) [more inside]
Is Psychometric g a Myth? - "As an online discussion about IQ or general intelligence grows longer, the probability of someone linking to statistician Cosma Shalizi's essay g, a Statistical Myth approaches 1. Usually the link is accompanied by an assertion to the effect that Shalizi offers a definitive refutation of the concept of general mental ability, or psychometric g." [more inside]
Icky face-pooping flesh mites are only the tip of the iceberg. You've heard that your gut bacteria are necessary to help you digest, meaning not all germs are bad. Without them, we couldn't digest healthily. But stop and look at how far our interconnectedness with other forms of life goes: 1. Human DNA itself is at least 8.3% ancient viruses; without one of these viruses you could never have been born. 2. Mitochondria in human cells originated when the same type of bacteria that causes typhus disease raided one of our cellular ancestors and instead of hijacking it was pressed into service. (The same origin as chloroplasts in plants from cyanobacteria). 3. Far more of the cells in your body are non-human microorganisms than actual human cells. This relationship is not just interconnectedness. This is integration. [more inside]
"As a climber goes up even higher in altitude, into the so-called death zone, the dangerously thin air above 26,000 feet, there is so little oxygen available that the body makes a desperate decision: it cuts off the digestive system. The body can no longer afford to direct oxygen to the stomach to help digest food because that would divert what precious little oxygen is available away from the brain. The body will retch back up anything the climber tries to eat, even if it’s as small as an M&M." -Excerpt from To the Last Breath: A Journey of Going to Extremes
How can we better understand the interplay of nature and nurture in determining our personalities, behavior, and vulnerability to disease? Perhaps we should be looking at identical twins. (National Geographic January 2012 cover story) [more inside]
Swimming around in a mixture of language and matter, humans occupy a particular evolutionary niche mediated by something we call 'consciousness'. To Professor Nicholas Humphrey we're made up of "soul dust": "a kind of theatre... an entertainment which we put on for ourselves inside our own heads." But just as that theatre is directed by the relationship between language and matter, it is also undermined by it. It all depends how you think it.
"It is only fitting that the story of the brain should be a visual one, for the visuals had the ancients fooled for millenniums. The brain was so ugly that they assumed the mind must lie elsewhere. Now those same skeletal silhouettes glow plump and brightly colored, courtesy of a variety of inserted genes encoding fluorescent molecules. A glossy new art book, “Portraits of the Mind,” hopes to draw the general reader into neuroscience with the sheer beauty of its images." Slide Shows: The Beautiful Mind and Portraits of the Mind [more inside]
Using a 3-D petri dish, Researchers at Brown University and Women & Infants Hospital of Rhode Island have built a completely functional artificial human ovary that will allow doctors to harvest immature human egg cells (oocytes) and grow them into mature, ready-to-be-fertilized human eggs outside the body. (In vitro) The advance could eventually help preserve fertility for women facing chemotherapy or other medical treatments that may be destructive to ovarian folliculogenesis. Press Release. Article link. (paywall) [more inside]
We may soon be able to clone Neanderthals. But should we? An essay from Archaeology Magazine examines the ethical, scientific and legal ramifications. (Via Heather Pringle's Time Machine blog, where essay author Zach Zorich posted a reply and elicited a response.) [more inside]
Why is the penis shaped like that? [T]he human penis is actually an impressive “tool” in the truest sense of the word, one manufactured by nature over hundreds of thousands of years of human evolution. You may be surprised to discover just how highly specialized a tool it is. Furthermore, you’d be amazed at what its appearance can tell us about the nature of our sexuality.
Get your learn on. 180+ ways of investigating the human brain = hours of fun for the whole family. Thanks to an innocuous question by a 5 year old, my entire evening is now being spent investigating and discussing the structure and workings of the human brain. This flash site lets you explore the workings of the brain according to 12 subject areas (each with subtopics which are not included in the "180" count), within each of which are 5 levels of organization from social to molecular, within each of which are three levels of explanation (beginner, intermediate, and advanced.) discovered via Wikipedia.
Any admixture would have to be driven by male Neanderthals. Two years ago we discussed morphological evidence of nontrivial interbreeding. Since then Neanderthal DNA has been examined for genetic support for this model of human evolution, largely contradicting the belief in Neanderthal contribution to modern humanity. Indeed any contribution from the Neanderthal gene pool to the evolution of modern humans might be very rare and indeed it appears that the best candidate gene thus (MC1R) far likely was a result of convergent evolution. [more inside]
The first Transhuman Conference On the Law of Transhuman Persons: Whether or not you believe humans are set to evolve into gods, or AI is destined to achieve self-awareness the idea of the Transhuman is a thought provoking concept. Philosophers have debated the nature of the self, of the human for millennia. Is it time to start drafting new laws to govern all possible sentient beings on this planet? or is it all just a science of fiction? a comfortable humanist illusion?