You Look Nice Today | A Journal of Emotional Hygiene is one of those podcasts all the kids are talking about these days. It's just a few guys, you know, talking, but it's newish, amusing, and one of the guys is Metafilter's Very Own™ MerlinMann.
posted on May 29, 2008 - View this thread

The Bugle is a topical comedic podcast by The Daily Show's John Oliver and fellow comedian Andy Saltzman. They style it an Audio Newspaper for a Visual World. Each weekly episode is about half an hour long.
posted on Nov 26, 2007 - View this thread

The Midwest Teen Sex Show is a podcast for teens and adults covering the wonderful, awkward, stimulating, sticky world of sex.
posted on Sep 2, 2007 - View this thread

How to build your very own balsawood crow, the poetry of Dennis Beerpint, Little Severin the Mystic Badger, plus lobster diagrams and of course the Binnacle of the Week await you at Hooting Yard. Celebrated in song and story, Hooting Yard (also a radio show and podcast) is the home of Frank Key, author of such works as Sydney the Bat is Awarded the Order of Lenin and A Complete and Utter History of Norwich.
posted on Apr 12, 2007 - View this thread

Merlin Mann's 43 Folders podcast is hilarious.
posted on Oct 26, 2005 - View this thread