The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
"If an NHS trust proposed today that it was going to introduce Viagra sales reps into men's genitourinary wards, or reps for walking aids to orthopaedic wards, the very least you'd expect would be some stout resistance. It is a measure of the strength of the association between "motherhood" and "buying stuff" that the presence of commercial representatives on maternity wards has been tolerated for so long."[more inside]
This Video Will Hurt
A detailed explanation of a fascinating field of science and medicine by the always interesting C.G.P. Grey.[more inside]
The Nazi Anatomists. "How the corpses of Hitler's victims are still haunting modern science—and American abortion politics."
A Life-Or-Death Situation. "As a bioethicist, Margaret "Peggy" Pabst Battin fought for the right of people to end their own lives. After her husband’s cycling accident, her field of study turned unbearably personal." Via.
Widespread fraud has been discovered in the case of an Indian generic drug manufacturer that makes generic Lipitor (atorvastatin calcium) and many other drugs. Ranbaxy has "pleaded guilty to seven federal criminal counts of selling adulterated drugs with intent to defraud." [more inside]
The drugs don't work : a modern medical scandal - "The doctors prescribing the drugs don't know they don't do what they're meant to. Nor do their patients. The manufacturers know full well, but they're not telling."
Just as Dante found it easier to conjure the pains of Hell than to evoke the joys of Heaven, so too do bioethicists find it easier to concoct the possible perils of a biotech-nanotech-infotech future than to appreciate how enhancements will contribute to flourishing lives. One of the chief goals of this symposium is to think about the indispensable role that virtue plays in human life. The chief motivating concern seems to be the fear that biotechnologies and other human enhancement technologies will somehow undermine human virtue. As we will see, far from undermining virtue, biotech, nanotech, and infotech enhancements will tend to support virtue; that is, they will help enable people to be actually good.
Bartolo Colon, now of the New York Yankees, underwent a controversial stem-cell treatment in the Dominican Republic to regain his old form.
Couples from Western countries, such as Australia, the US, and the UK are turning to surrogates in India to carry their babies. [more inside]
The Torture Papers. "In the most comprehensive investigation to date of health professionals' involvement in the CIA's 'enhanced' interrogation program (EIP), Physicians For Human Rights has uncovered evidence that indicates the Bush administration apparently conducted illegal and unethical human experimentation and research on detainees in CIA custody. The apparent experimentation and research appear to have been performed to provide legal cover for torture, as well as to help justify and shape future procedures and policies governing the use of the 'enhanced' interrogation techniques. The PHR report, Experiments in Torture: Human Subject Research and Evidence of Experimentation in the 'Enhanced' Interrogation Program, is the first to provide evidence that CIA medical personnel engaged in the crime of illegal experimentation after 9/11, in addition to the previously disclosed crime of torture." [more inside]
Are the Rules That Determine Who Can Donate Blood Discriminatory? Canadian AIDS researchers Dr. Mark Wainberg and Dr. Norbert Gilmore say that while the ban on blood donation from men who have sex with other men may have been ethically and scientifically justified in the 1980's, it no longer makes sense. (CMAJ.) Even though the US FDA reaffirmed their long-standing ban in 2007, they plan to revisit the policy in June. [more inside]
Provoking pro-choice advocates, Oklahoma passed two highly restrictive abortion laws on Tuesday. One (rtf file) requires doctors to show women an ultrasound of their fetus and point out its physical characteristics — even if the patient was impregnated through rape or incest. The second (rtf file) stipulates that doctors cannot be sued if they decide to lie to an expectant mother regarding her baby's birth defects. A third requires clinics to post signs telling patients they cannot be forced to have an abortion. The first law prompted an immediate lawsuit from Tulsa's only abortion clinic. [more inside]
Was it triage or murder? A disturbing NY Times story about the choices made by certain medical staff at a New Orleans hospital during Hurricane Katrina. Long and not easy reading.
Neurosecurity: security and privacy for neural devices. "An increasing number of neural implantable devices will become available in the near future due to advances in neural engineering. This discipline holds the potential to improve many patients' lives dramatically by offering improved—and in some cases entirely new—forms of rehabilitation for conditions ranging from missing limbs to degenerative cognitive diseases. The use of standard engineering practices, medical trials, and neuroethical evaluations during the design process can create systems that are safe and that follow ethical guidelines; unfortunately, none of these disciplines currently ensure that neural devices are robust against adversarial entities trying to exploit these devices to alter, block, or eavesdrop on neural signals. The authors define 'neurosecurity'—a version of computer science security principles and methods applied to neural engineering—and discuss why neurosecurity should be a critical consideration in the design of future neural devices." [Via Mind Hacks]
The Stupidity of Dignity: Conservative bioethics' latest, most dangerous ploy. Steven Pinker reviews Human Dignity and Bioethics, the latest report from the President's Council on Bioethics. [more inside]
The blood substitute PolyHeme has been previously discussed on MetaFilter, but new evidence shows that PolyHeme actually raises the chances of death by nearly 30%. PolyHeme was notable mostly for the reaction to its clinical trials, which, controversially, did not require patient consent.
The Checklist - "If a new drug were as effective at saving lives as Peter Pronovost’s checklist, there would be a nationwide marketing campaign urging doctors to use it" [single page]
Do Not Resuscitate. "For families facing the impending death of a loved one, few topics trigger more anguish than the Do Not Resuscitate order... There is little ambiguity in a DNR order: Emergency medical staff must withhold CPR and other life-reviving treatments if the patient's heart or breathing stops, allowing death." But, DNR orders aren't always cut-and-dried. There are many situations that complicate the medical professional's decision to comply. Related: Some people have opted to get a "D.N.R." tattoo, but others have wondered if it will hold up in court as a legal directive. [First link Via].
U.S. military practices genetic discrimination in denying benefits. "Those medically discharged with genetic diseases are left without disability or retirement benefits. Some are fighting back."
Paternity Discrepancy. "My little boy was there, he was up at bat, and I started yelling for him, 'Go Matthew [not his real name]! Knock it out of the park!' And another man started screaming for Matthew. Louder than me. I looked over, and I looked at him, and I was like, Who is this guy? And I looked at my son, and I looked at him … and they were identical."
Examining Bush's stem cell policy, two years later. Kinsley: Put it all together, and the stem cells that can squeeze through Bush's loopholes are far less promising than they seemed two years ago, while the general promise of embryonic stem cells burns brighter than ever. If you claim to have made an anguished moral decision, and the factual basis for that decision turns out to be faulty, you ought to reconsider or your claim to moral anguish looks phony. But Bush's moral anguish was suspect from the beginning, because the policy it produced makes no sense.
Organ donation has become a hot topic on Me Fi lately. Unfortunately, this thread has not spawned the best discussion. But the ethics of organ tansplantation can become difficult. Do donors have the right to specify who gets their organs? If they do, what does that imply for living donors; in other words, are you really volunteering to donate that kidney to your brother? And should we have an opt-in or opt-out system? Most religions approve of organ donation; even Jehovah's Witnesses that do not accept blood transfusions. And of course, the US government is involved, for better or worse. Not everyone thinks organ donation is good. More links here and here.
Unmitigated gall. The illegal aliens who got two hearts and two lungs for their daughter REFUSED to have any of her organs donated when it was clear she was brain-dead...
Convict Heart Transplant A 31 year old 2 time felon just got a heart transplant, costing tax payers close to $1 million dollars. With an annual additional cost of $15,000. Right? Wrong? I'm not so sure.
Lots of posts lately about the election, about other strange things, (and especially about my favorite subject to not read: Nader) and we haven't had a knock-down drag-out argument about ethics for a while. So I thought I'd start one about this. Using up humans to collect medical data is unquestionably immoral and those who do it should be hung, if not put to death by torture. The question is whether those of us who had nothing to do with the collection of that data and have not done anything immoral become immoral by using data collected that way in order to save lives. I'm going to make three posts below, so be patient.