How Tripping On Mushrooms Changes The Brain - "New research [pdf] suggests that psilocybin, the main psychoactive ingredient in magic mushrooms, sprouts new links across previously disconnected brain regions, temporarily altering the brain's entire organizational framework." [more inside]
"Postpartum depression isn’t always postpartum. It isn’t even always depression. A fast-growing body of research is changing the very definition of maternal mental illness, showing that it is more common and varied than previously thought." ‘Thinking of Ways to Harm Her’ and "After Baby, an Unraveling". [more inside]
A Life-Or-Death Situation. "As a bioethicist, Margaret "Peggy" Pabst Battin fought for the right of people to end their own lives. After her husband’s cycling accident, her field of study turned unbearably personal." Via.
National Institute of Mental Health director Thomas Insell reports that NIMH will phase out its reliance on the Diagnostic and Statistical Manual of Mental Disorders (DSM), in favor of a revamped psychiatric diagnostic system based on "genetics, imaging, cognitive science, and other levels of information to lay the foundation for a new classification system." [more inside]
Falling STAR*D?: It is common practice for psychiatrists to switch depressive patients between different antidepressants if their current drug does not evince a symptomatic response. Despite clinical wisdom supporting this, little empirical, controlled evidence exists to direct “switching” protocols (e.g. if a patient with Z characteristics is on drug X, is it usually better to switch to drug A, B, or C? Will switching help at all?) in the psychopharmacological treatment of depression. The NIMH-funded STAR*D (Sequenced Alternatives to Relieve Depression) study aimed to address these questions of treatment direction in a very large (n>4000), “real-world” sample using a multi-phase treatment plan with different drugs (and cognitive therapy) at every step to maximize chances of eventual remission. Overall, the NIMH reported that about 67% of patients eventually achieved remission, with few differences in effectiveness between different types of treatment at each step. However, researchers and commentators have raised concerns regarding inconsistent reporting of outcomes, after-the-fact changes in study design and analysis, and other issues that may have inflated, partially invalidated, or misrepresented widely reported treatment outcomes. These inequities may also have implications for the secondary moderator analyses (i.e. does trait A predict switching to X or Y is better?) that were a major reason for the study. [more inside]
Locke, Johnson, Kierkegaard, Freud, and dozens of other historical figures on the subject of obsessive-compulsive disorder. [more inside]
The Triumph of New-Age Medicine "Medicine has long decried acupuncture, homeopathy, and the like as dangerous nonsense that preys on the gullible. Again and again, carefully controlled studies have shown alternative medicine to work no better than a placebo. But now many doctors admit that alternative medicine often seems to do a better job of making patients well, and at a much lower cost, than mainstream care—and they’re trying to learn from it." [more inside]
New Scientist Special Report: Living in Denial. Includes articles by Michael Shermer, founding publisher of Skeptic Magazine [more inside]
The "Still Face" Paradigm (YT video) designed by Dr. Edward Tronick of Harvard and Childrens Hospital’s Child Development Unit, is an experiment which shows us how a 1-year old child will react to a suddenly unresponsive parent. It allows us to understand how a caregiver's interactions and emotional state can influence many aspects of an infant's social and emotional development. [more inside]
“The psychoanalytic mystique was overwhelming. It was a little bit like the evangelical movement.” How Aaron Beck and Cognitive Behavioral Therapy helped increase empiricism in psychotherapy.
“It would be completely unethical to give the drug to someone else,” he said, “but if you’re in a marriage and want to maintain that relationship, you might take a little booster shot yourself every now and then. Even now it’s not such a far-out possibility that you could use drugs in conjunction with marital therapy.”
The Economist on Drugs -- Scientists in North America, Europe and Israel are studying the use of MDMA, LSD, hallucinogenic mushrooms, marijuana and other banned psychoactive substances in treating conditions such as anxiety, cluster headaches, addiction and obsessive-compulsive disorder. They are supported by private funds from a handful of organisations: the Beckley Foundation in Britain; the Heffter Research Institute and the Multidisciplinary Association for Psychedelic Studies (MAPS) in America. [related]
Are you batshitinsane? Viruses and/or bacteria may be the cause.
Dictionary of Disorder - shaping the DSM
Trust-Building Hormone Short-Circuits Fear In Humans Oxytocin, a brain chemical recently found to boost trust, also suppresses the activity in the amygdala where fear is generated. This could be a breakthrough for those who suffer from any type of social avoidance disorder.
"An autopoietic system is one organised to respond to the world. Prod it and it will react homeostatically, striving to reach a new accommodation that preserves its integrity. There is a global cohesion - a memory of what the system wants to be - that reaches down to organise the parts even while those parts may be adding up to produce the functioning whole."
No pain, no gain, they say, and when it comes to real pain, the inverse is true as well. "We now have research indicating there's a memory of chronic pain," said Dr. Doris K. Cope, director of chronic and cancer pain for the University of Pittsburgh Medical Center. It changes the genic code sometimes, it changes the biochemistry, and it causes new proteins to be formed." Or in other words, the more pain you have, the more pain you have. (More on this.) It's no wonder, then, that more money is spent on pain relief than any other medical problem, and that there has been so much pain research and so many clinical trials revealing such painful facts as redheads feel more pain, men feel less pain, and that there's a genetic difference between tough guys and wimps. (Much more pain inside.)
The mind-body divide in medicine, whether having medicine embrace the understanding of the psychological aspects of symptoms of pain, for example, is simply a matter of working toward medicalizing psychology. How much is the brain and psychology taken into account in the medical profession?
Utah Leads Nation in Rate of Anti-Depressant Use. It is interesting (to me) in that the people doing the study credit a "Mother of Zion" syndrome of married Mormon women putting on the happy face regardless of how happy they truly are. My state is up at the top also. Could be all the rain I guess. . .*sigh*
What if the 'placebo effect' is as unreal as a sugar pill? Danish researchers who have looked at 114 clinical trials involving placebos found "little evidence in general that placebos had powerful clinical effects. Although placebos had no significant effects on objective or binary outcomes, they had possible small benefits in studies with continuous subjective outcomes and for the treatment of pain. Outside the setting of clinical trials, there is no justification for the use of placebos." News links here and here.