Inside the insectary - "These gene drives, they're able to copy themselves. So instead of half of the offspring inheriting the gene drive, almost all of them do. So what happens is that it spreads and it spreads and it spreads. And this is the fantastic thing. Because it allows that gene to be selfish in a population. And in a very short amount of time you can actually transform an entire wild population into a modified population. It's powerful." (previously: 1,2,3)
Maia Szalavitz [mefi's own maias] talks about her new book, Unbroken Brain: A Revolutionary New Way of Understanding Addiction on Fresh Air with Terry Gross (transcript) - "We have this idea that if we are just cruel enough and mean enough and tough enough to people with addiction, that they will suddenly wake up and stop, and that is not the case."
Magic Mushroom Drug Lifts Depression in Human Trial - "The findings show that more research in this field is now needed. 'This is the first time that psilocybin has been investigated as a potential treatment for major depression', says lead author Dr Robin Carhart-Harris, Imperial College London."
Humans 2.0 - "With CRISPR, scientists can change, delete, and replace genes in any animal, including us. Working mostly with mice, researchers have already deployed the tool to correct the genetic errors responsible for sickle-cell anemia, muscular dystrophy, and the fundamental defect associated with cystic fibrosis. One group has replaced a mutation that causes cataracts; another has destroyed receptors that H.I.V. uses to infiltrate our immune system." [more inside]
The CRISPR Revolution [ungated: 1,2,3] - "Biologists continue to hone their tools for deleting, replacing or otherwise editing DNA and a strategy called CRISPR has quickly become one of the most popular ways to do genome engineering. Utilizing a modified bacterial protein and a RNA that guides it to a specific DNA sequence, the CRISPR system provides unprecedented control over genes in many species, including perhaps humans. This control has allowed many new types of experiments, but also raised questions about what CRISPR can enable." [more inside]
Locked-In Man - "Martin Pistorius spent more than a decade unable to move or communicate, fearing he would be alone, trapped, forever. NPR's new show Invisibilia tells how his mind helped him create a new life."
How Tripping On Mushrooms Changes The Brain - "New research [pdf] suggests that psilocybin, the main psychoactive ingredient in magic mushrooms, sprouts new links across previously disconnected brain regions, temporarily altering the brain's entire organizational framework." [more inside]
Scientists Progress in Quest to Grow Muscle Tissue in Labs - "The researchers are now working on optimizing the growth of human muscle tissue, including finding a way to get blood flow to the tissue, the best source of cells and the best growing medium for the cells."
What US Health Care Needs Medical doctor and writer Atul Gawande gave the commencement address recently at Stanford's School of Medicine. In it he lays out very precisely and in a nonpartisan way what is wrong with the institution of medical care in the US — why it is both so expensive and so ineffective at delivering quality care uniformly across the board. (via)
How American Health Care Killed My Father After the needless death of his father, the author, a business executive, began a personal exploration of a health-care industry that for years has delivered poor service and irregular quality at astonishingly high cost. It is a system, he argues, that is not worth preserving in anything like its current form. And the health-care reform now being contemplated will not fix it. Here’s a radical solution to an agonizing problem. (via mr) [more inside]
The Economist on Drugs -- Scientists in North America, Europe and Israel are studying the use of MDMA, LSD, hallucinogenic mushrooms, marijuana and other banned psychoactive substances in treating conditions such as anxiety, cluster headaches, addiction and obsessive-compulsive disorder. They are supported by private funds from a handful of organisations: the Beckley Foundation in Britain; the Heffter Research Institute and the Multidisciplinary Association for Psychedelic Studies (MAPS) in America. [related]
Search for an Rx - We asked Johns Hopkins administrators, physicians, and researchers about the health of a system Americans rely on to keep them healthy. Afterall, an ounce of prevention... [more inside]
Scientists Repurpose Adult Cells - "Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a variety of illnesses and sidestep the political and ethical quagmires associated with embryonic stem cell research." [nature abstract, nature writeup, audio announcement]
Thirty-six years after the National Commission on Marihuana and Drug Abuse recommended that "simple possession" of pot be decriminalised, Rep. Barney Frank (D-Mass.) has introduced a bill, co-sponsored by Rep. Ron Paul (R-Texas), to remove federal criminal penalties for possession of up to 100 grams (about three-and-a-half ounces) of marijuana and the not-for-profit transfer of up to one ounce (28.3 grams). Drug reform advocates
lit up hailed the legislation as "an important step toward bringing federal law into line with scientific fact, practical reality and public opinion." Is America, at long last, having a collective moment of sanity?
Outcasts in Their Own Villages "More than one million young women with the condition are scattered throughout the so-called fistula belt that stretches across the southern hem of the Sahara from Eritrea to Mali. Because of their severe incontinence and smell, many have been ostracized by their families and villages and live by themselves or with fellow fistula sufferers. They are the lepers of the desert." [also see]