A pilot study testing for statistically significant blood biomarkers found in early-onset MDD: "Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression" [PDF], published by the online, open source journal Translational Psychiatry**, April 2012, Volume 2. [more inside]
A gene variant associated with serotonin transport (STG) , and normally associated with depression is strangely more prevalent, but also less likely to induce depression in collectivistic East Asian cultures. The study took data from 29 countries, and found a consistent trend towards this same genetic variant being strongly associated with episodes of major depression in Western cultures.
A review of the current state of gender based brain research shows that women and men differ both in the way their brains are constructed and in how they function.
..correlation between brain region size in adults and sex steroid action in utero suggests that at least some sex differences in cognitive function do not result from cultural influences or the hormonal changes associated with puberty--they are there from birth.Treatment for such things as schizophrenia and depression will likely have gender specific variations in the future. Previously, brain research that examined gender differences was considered controversial because it was argued that the results might give rise to more sex discrimination against women. That view may be changing.