...Objectives This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions...
Results Psilocybin produced a range of acute perceptual changes, subjective experiences, and labile moods including anxiety. Psilocybin also increased measures of mystical experience. At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by community observers.
Conclusions When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences. The ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
Out of the mist of the beginning of our era there looms a pageant of mythical figures whose vast, superhuman contours might people the walls of another Sistine Chapel. Their countenances and gestures, the roles in which they are cast, the drama which they enact, would yield images different from the biblical ones on which the imagination of the beholder was reared, yet strangely familiar to him and disturbingly moving. The stage would be the same, the theme as transcending: the creation of the world, the destiny of man, fall and redemption, the first and the last things. But how much more numerous would be the cast, how much more bizarre the symbolism, how much more extravagant the emotions! Hans Jonas
Into the Gnostic.