In the past several years, many scientists have become afflicted with a serious case of doubt — doubt in the very institution of science... So we sent scientists a survey asking this simple question: If you could change one thing about how science works today, what would it be and why? We heard back from 270 scientists all over the world, including graduate students, senior professors, laboratory heads, and Fields Medalists. They told us that, in a variety of ways, their careers are being hijacked by perverse incentives. The result is bad science.
The Reproducibility Project out of UVa recently published their findings in Science: Estimating the reproducibility of psychological science
We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. ... The mean effect size (r) of the replication effects (Mr = 0.197, SD = 0.257) was half the magnitude of the mean effect size of the original effects (Mr = 0.403, SD = 0.188), representing a substantial decline. Ninety-seven percent of original studies had significant results (P < .05). Thirty-six percent of replications had significant results;[more inside]
The Reproducibility Initiative "Here’s how it is supposed to work. Let’s say you have found a drug that shrinks tumors. You write up your results, which are sexy enough to get into Nature or some other big-name journal. You also send the Reproducibility Initiative the details of your experiment and request that someone reproduce it. A board of advisers matches you up with a company with the experience and technology to do the job. You pay them to do the job...and they report back whether they got the same results."