MetaFilter posts tagged with research and depression

Anti-depressants, Serotonin and Depression

OmieWise — Thu, 17 Jan 2008 08:12:07 -0800

"Researchers found that failing to publish negative findings inflated the reported effectiveness of all 12 of the antidepressants studied." See also: Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature. NEJM paper referenced. (Subscription required) Older: Antidepressants Versus Placebos: Meaningful Advantages Are Lacking,
but, Small Effects Are Not Trivial From a Public Health Perspective.

Treating depression with ketamine

casconed — Wed, 09 Aug 2006 13:20:27 -0800

Ketamine has been found to "significantly" improve symptoms of depression by influencing glutamate levels in the brain. A Forbes article notes that 70% of patients say improvement, and up to 29% were "nearly symptom free within one day". However, research into the effects of ketamine on depression is not exactly new.

Seductive Solutions for Rough Illnesses

daksya — Tue, 08 Nov 2005 19:43:59 -0800

Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

When drug companies hide data

Lusy P Hur — Sun, 06 Jun 2004 13:48:17 -0800

When drug companies hide data.

"The attorney general's civil suit accuses the drug giant GlaxoSmithKline of committing fraud by concealing negative information about Paxil, a drug used to treat depression. The suit says that the company conducted five clinical trials of Paxil in adolescents and children, yet published only one study whose mixed results it deemed positive. The company sat on two major studies for up to four years, although the results of one were divulged by a whistle-blower at a medical conference in 1999 and all of the studies were submitted to the Food and Drug Administration in 2002 when the company sought approval for new uses of Paxil. At that time it became apparent that Paxil was no more effective than a placebo in treating adolescent depression and might even provoke suicidal thoughts.

My Dad was on Paxil until 26 days ago..... that's when he shot himself.

Samizdata — Thu, 23 May 2002 09:15:21 -0800

Stanford links genius and manic depression... I feel SO much better now... (via FARK)