"We were concerned that the study would raise a lot of controversy and be misused," Pardo said. "We were right." Some practitioners treat autistic children with the anti-inflammatory intravenous immunoglobulin, citing a study by Carlos Pardo, et al. showing inflammation in the brains of deceased autistic patients. Pardo: "modulators of immune reactions (e.g. intravenous immunoglobulins, IVIG) WOULD NOT HAVE a significant effect." Others, following the work of Simon Baron-Cohen on autism and the male brain, treat autistic children with testosterone inhibitors, a prospect which Baron-Cohen says "fills me with horror." Another anti-inflammatory treatment, hyperbaric therapy, is supported by one recent clinical trial, but looks bad in another. Side effects include horrible death by fire. (via the Chicago Tribune)
posted by escabeche on Nov 23, 2009 - 49 comments

On behalf of medical organizations, universities, & individual patients, pathologists and genetics researchers, the ACLU has filed a lawsuit against Utah-based Myriad Genetics and the US Patent and Trademark Office. Myriad holds the US patents to the BRCA1 and BRCA2 genes, associated with hereditary causes of breast and ovarian cancers. Their patents guarantee the company the right to prevent anyone else from testing or studying those genes, which the ACLU says is unconstitutional and inhibits researchers from finding treatments and cures. [more inside]
posted by zarq on May 13, 2009 - 64 comments

Brain Researchers Open Door to Editing Memory : spotless minds might be closer than we think.
posted by grapefruitmoon on Apr 16, 2009 - 20 comments

In the background behind attention-grabbing headlines about famous (and wannabe-famous) cancer patients, a quiet revolution may be on the brink of changing oncology. [more inside]
posted by bunnycup on Feb 16, 2009 - 42 comments

The Economist on Drugs -- Scientists in North America, Europe and Israel are studying the use of MDMA, LSD, hallucinogenic mushrooms, marijuana and other banned psychoactive substances in treating conditions such as anxiety, cluster headaches, addiction and obsessive-compulsive disorder. They are supported by private funds from a handful of organisations: the Beckley Foundation in Britain; the Heffter Research Institute and the Multidisciplinary Association for Psychedelic Studies (MAPS) in America. [related]
posted by kliuless on Dec 28, 2008 - 43 comments

Search for an Rx - We asked Johns Hopkins administrators, physicians, and researchers about the health of a system Americans rely on to keep them healthy. Afterall, an ounce of prevention... [more inside]
posted by kliuless on Dec 3, 2008 - 15 comments

Claudia Castillo's new bronchus is the result of stem-cell research. The first hollow tube body part is transplanted with no rejection issues. A lab in Italy stripped the donor trachea of living tissue leaving a collagen matrix. Claudia's stem cells were grown in a Bristol lab, (all 6 million of them) to flesh it out, so to speak. Epithelial cells from her nose & lungs formed the lining. But...... [more inside]
posted by Wilder on Nov 19, 2008 - 37 comments

Scientists Repurpose Adult Cells - "Scientists have transformed one type of fully developed adult cell directly into another inside a living animal, a startling advance that could lead to cures for a variety of illnesses and sidestep the political and ethical quagmires associated with embryonic stem cell research." [nature abstract, nature writeup, audio announcement]
posted by kliuless on Aug 27, 2008 - 21 comments

The blood substitute PolyHeme has been previously discussed on MetaFilter, but new evidence shows that PolyHeme actually raises the chances of death by nearly 30%. PolyHeme was notable mostly for the reaction to its clinical trials, which, controversially, did not require patient consent.
posted by scrump on Apr 29, 2008 - 19 comments

"Researchers found that failing to publish negative findings inflated the reported effectiveness of all 12 of the antidepressants studied." See also: Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature. [more inside]
posted by OmieWise on Jan 17, 2008 - 137 comments

The Checklist - "If a new drug were as effective at saving lives as Peter Pronovost’s checklist, there would be a nationwide marketing campaign urging doctors to use it" [single page]
posted by Gyan on Jan 2, 2008 - 65 comments

The Placebo Effect In Action. "When patients believe a drug will help them, they sometimes heal themselves" (a report on a new study from Columbia University and the University of Michigan). And, an additional take on the Placebo Effect from the Skeptic's Dictionary.
posted by amyms on Aug 2, 2007 - 19 comments

Coverage with Evidence Development. Never heard of it? Me neither, until today. It's what they call this idea: if you want to be covered by Medicare, you're forced to participate in medical research. The AMA approves (article abstract only). So much for informed consent.
posted by ikkyu2 on Sep 4, 2006 - 26 comments

Nature has a somewhat technical but free supplement on stem cells (alongwith a podcast and related blog).
posted by Gyan on Jul 2, 2006 - 6 comments

Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature
posted by daksya on Nov 8, 2005 - 60 comments

No pain, no gain, they say, and when it comes to real pain, the inverse is true as well. "We now have research indicating there's a memory of chronic pain," said Dr. Doris K. Cope, director of chronic and cancer pain for the University of Pittsburgh Medical Center. It changes the genic code sometimes, it changes the biochemistry, and it causes new proteins to be formed." Or in other words, the more pain you have, the more pain you have. (More on this.) It's no wonder, then, that more money is spent on pain relief than any other medical problem, and that there has been so much pain research and so many clinical trials revealing such painful facts as redheads feel more pain, men feel less pain, and that there's a genetic difference between tough guys and wimps. (Much more pain inside.)

posted by taz on Sep 20, 2004 - 31 comments

When drug companies hide data.

"The attorney general's civil suit accuses the drug giant GlaxoSmithKline of committing fraud by concealing negative information about Paxil, a drug used to treat depression. The suit says that the company conducted five clinical trials of Paxil in adolescents and children, yet published only one study whose mixed results it deemed positive. The company sat on two major studies for up to four years, although the results of one were divulged by a whistle-blower at a medical conference in 1999 and all of the studies were submitted to the Food and Drug Administration in 2002 when the company sought approval for new uses of Paxil. At that time it became apparent that Paxil was no more effective than a placebo in treating adolescent depression and might even provoke suicidal thoughts.

My Dad was on Paxil until 26 days ago..... that's when he shot himself.
posted by Lusy P Hur on Jun 6, 2004 - 47 comments

Patient confidentiality vs. cancer research. New rules on patient confidentiality prevent "research that recognises dangerous side effects of treatments and it would prevent research that would recognise avoidable causes of diseases and death. " What is more important: 'medical progress' or 'your medical file'?
posted by nonharmful on May 19, 2001 - 2 comments

Fighting cancer one computer at a time - Following in the footsteps of the SETI@Home project, a new program is being launched enabling you to use your spare computer power helping to research new treatments in the fight against cancer.
posted by Noah on Apr 3, 2001 - 5 comments

Lots of posts lately about the election, about other strange things, (and especially about my favorite subject to not read: Nader) and we haven't had a knock-down drag-out argument about ethics for a while. So I thought I'd start one about this. Using up humans to collect medical data is unquestionably immoral and those who do it should be hung, if not put to death by torture. The question is whether those of us who had nothing to do with the collection of that data and have not done anything immoral become immoral by using data collected that way in order to save lives. I'm going to make three posts below, so be patient.
posted by Steven Den Beste on Oct 22, 2000 - 30 comments

According to a double-blind study, Zicam, an over the counter nasal spray, cuts duration of the common cold by 75%. Now when I call in sick to work, I'll have to say I have cancer.
posted by grumblebee on Oct 12, 2000 - 8 comments

http://www.guardianunlimited.co.uk/international/story/0,3604,372067,00.html Thousands of South American indians were infected with measles, killing hundreds, in order to for US scientists to study the effects on primitive societies of natural selection.
posted by hobbes on Sep 22, 2000 - 5 comments

NASA scientists are successfully growing heart tissue in bioreactors. Need a kidney? No prob, need a heart? Got one. With tech like this, I should probably take up smoking!
posted by mathowie on Oct 6, 1999 - 0 comments