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Constitutive formation of caveolae in a bacterium.

Constitutive formation of caveolae in a bacterium. [Full Text]
Caveolin plays an essential role in the formation of characteristic surface pits, caveolae, which cover the surface of many animal cells. The fundamental principles of caveola formation are only slowly emerging. Here we show that caveolin expression in a prokaryotic host lacking any intracellular membrane system drives the formation of cytoplasmic vesicles containing polymeric caveolin. Vesicle formation is induced by expression of wild-type caveolins, but not caveolin mutants defective in caveola formation in mammalian systems. In addition, cryoelectron tomography shows that the induced membrane domains are equivalent in size and caveolin density to native caveolae and reveals a possible polyhedral arrangement of caveolin oligomers. The caveolin-induced vesicles or heterologous caveolae (h-caveolae) form by budding in from the cytoplasmic membrane, generating a membrane domain with distinct lipid composition. Periplasmic solutes are encapsulated in the budding h-caveola, and purified h-caveolae can be tailored to be targeted to specific cells of interest.
Elio Schaechter writes in plain English about how fantastically amazing and unexpected the researchers actually pulling this off is, and he also talks about it in more detail in his podcast.
posted by Blasdelb on Oct 18, 2012 - 22 comments

Provirophages and transpovirons as the diverse mobilome of giant viruses

Provirophages and transpovirons as the diverse mobilome of giant viruses
Abstract: A distinct class of infectious agents, the virophages1 that infect giant viruses of the Mimiviridae family, has been recently described. Here we report the simultaneous discovery of a giant virus of Acanthamoeba polyphaga (Lentille virus) that contains an integrated genome2 of a virophage (Sputnik 2), and a member of a previously unknown class of mobile genetic elements3, the transpovirons4. The transpovirons are linear DNA elements of ∼7 kb [kilobases]5 that encompass six to eight protein-coding genes, two of which are homologous6 to virophage genes. Fluorescence7 in situ hybridization8 showed that the free form of the transpoviron replicates within the giant virus factory and accumulates in high copy numbers inside giant virus particles, Sputnik 2 particles, and amoeba cytoplasm. Analysis of deep-sequencing data showed that the virophage and the transpoviron can integrate9 in nearly any place in the chromosome of the giant virus host and that, although less frequently, the transpoviron can also be linked to the virophage chromosome. In addition, integrated fragments of transpoviron DNA were detected in several giant virus and Sputnik genomes. Analysis of 19 Mimivirus strains revealed three distinct transpovirons associated with three subgroups of Mimiviruses. The virophage, the transpoviron, and the previously identified self-splicing introns10 and inteins11 constitute the complex, interconnected mobilome12 of the giant viruses and are likely to substantially contribute to interviral gene transfer.
[Full Text PDF] and two explanations in English [more inside]
posted by Blasdelb on Oct 16, 2012 - 28 comments

"Please state where and when this card was found and then put it in the nearest Post Office."

Oldest message in a bottle found. The bottle was released as part of a research project tracking deep ocean currents. (Via socimages, via boingboing.)
posted by NoraReed on Oct 15, 2012 - 25 comments

*This* is the science of sound and matter.

Two elements: tempo and volume. Researchers at the Sundance Research Facility have finally discovered how to turn sound into matter.
posted by Dr. Fetish on Oct 4, 2012 - 12 comments

"Cocaine for Snowblindness"

You're about to be the base doctor at Halley Research Station in Antarctica for a year. For ten months, no one gets in or out. Fourteen lives are in your hands, including your own. What do you put in your medical kit? And how do your choices differ from those of your predecessors (Eric Marshall and Edward Wilson) a century ago?
posted by zarq on Oct 2, 2012 - 8 comments

Red Pill or Blue Pill? First, take off those 3D glasses.

The drugs don't work : a modern medical scandal - "The doctors prescribing the drugs don't know they don't do what they're meant to. Nor do their patients. The manufacturers know full well, but they're not telling."
posted by Gyan on Sep 22, 2012 - 76 comments

Modern Times: The Way of All Flesh (1997)

A documentary by Adam Curtis on Henrietta Lacks and HeLa cell line created from her cells. Previously. Previously.
posted by hat_eater on Sep 4, 2012 - 7 comments

Marinexplore

Have you ever wondered what the water temperature off the Kamchatka Peninsula is? What about the wind speed in the Andaman Sea? Or maybe you’re losing sleep over the chlorophyll levels in the South Pacific. Fortunately, all of that information –- and 450 million other data points collected from oceanographic instruments around the world –- is freely and easily accessible thanks to the Marinexplore project. [more inside]
posted by Egg Shen on Aug 28, 2012 - 3 comments

There are fewer microbes out there than you think

There are fewer microbes out there than you think. New estimate reduces the number of microbes on Earth by around half. [more inside]
posted by Blasdelb on Aug 28, 2012 - 38 comments

LSD absolutely had helped them solve their complex, seemingly intractable problems

"The Heretic: For decades, the U.S. government banned medical studies of the effects of LSD. But for one longtime, elite researcher, the promise of mind-blowing revelations was just too tempting." [more inside]
posted by andoatnp on Jul 30, 2012 - 113 comments

The Longest Time (Coral Triangle Edition)

Billy Joel has now officially endorsed - The Longest Time (Coral Triangle Edition), by the Barber Lab Quartet [more inside]
posted by Blasdelb on Jul 18, 2012 - 17 comments

Does anesthesiology have a problem? Final version of report suggests Fujii will take retraction record, with 172

In the wake of a very thorough and damning statistical analysis of 168 of his papers, published in March, Japanese investigators have concluded that Yoshitaka Fujii, fabricated his results in at least 172 published studies; shattering the previous record for most retracted papers. Considered an expert in postoperative nausea and vomiting, his "incredibly nice" findings drew scrutiny in 2000, but he continued to publish prolifically for more than a decade. Here are the published results of the Japanese Society of Anesthesiology's Special Investigation Committee, with an annotated list of all of his papers (PDF). The Retraction Watch also considers not only the depth of Fujii's betrayal but also whether the discipline of anesthesiology itself has a problem as it weighs in. [more inside]
posted by Blasdelb on Jul 8, 2012 - 33 comments

Turn your house into a giant battery.

"You could turn your home into a battery," said researcher Neelam Singh. Researchers at Rice University have created paints that act as rechargeable lithium-ion batteries. They can be painted onto virtually any surface, and can be charged with a solar cell. Full paper.
posted by stoneweaver on Jun 29, 2012 - 42 comments

The Viable Zombie

“[...] it took more than a dozen calls to work out the details of her zombie contagion. “After about the 17th time,” says McGuire, “I called and said, ‘If I did this, this, this, this, this, this and this, could I raise the dead?’ And got, ‘Don’t … don’t do that.’ And at that point, I knew I had a viable virus.”
posted by batmonkey on Jun 27, 2012 - 70 comments

Too many trainee positions in biomedical research

The U.S. National Institute of Heath has urged steps to curb growth in "training" positions in biomedical research (report). [more inside]
posted by jeffburdges on Jun 16, 2012 - 39 comments

Publish or Perish

Are bias and fraud damaging the existing public trust in scientific and medical research? (previously) [more inside]
posted by jeffburdges on May 13, 2012 - 35 comments

The Avian Flu: Transparency vs. Public Safety

"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets." After an extensive, months-long debate, one of two controversial papers showing ways the H5N1 "avian" influenza virus could potentially become transmissible in mammals with only 3 or 4 mutations was published in Nature today. The journal included an editorial on the merits and drawbacks of "publishing risky research" with regard to biosafety. The debate included an unprecedented recommendation by The US National Science Advisory Board for Biosecurity (NSABB) to block publication -- a decision they later reversed. (Via: 1, 2) Nature's special report has additional articles, including interviews with the teams behind both papers.
posted by zarq on May 3, 2012 - 37 comments

Wanna see some dirty books?

A researcher at St. Andrews University is using a tool called a densitometer to measure which pages in medieval manuscripts are the dirtiest, and therefore the most frequently read. The complete (and well-illustrated) study is available online from the Journal of Historians of Netherlandish Art. [more inside]
posted by Horace Rumpole on Apr 24, 2012 - 12 comments

Computer Science: Still have Byte? Or Down to Bits?

While growth prospects in the field are incredibly high, recent trends, such as "tools grow[ing] more advanced" (see Adobe Flash Builder or MS Visual Studio) have had people wondering over the past few years if computer science has much room for growth left. Some question whether it is alive. Others, such as Carnegie Mellon, say not so fast. In any case, employment has been a bit iffy (/.). There is the possibility that Computer Science is simply growing up (PDF), then again the U of Florida decided to say good bye to it this past week. But hey, if you are not going to that University, and still are shooting for computer science, here are some tips.
posted by JoeXIII007 on Apr 23, 2012 - 57 comments

To-Go-Bots

MIT is leading an NSF-funded project with researchers from University of Pennsylvania and Harvard that aims to enable anyone to "design, customize and print a specialized robot in a matter of hours." Constructed from "cyber-physical primitives," the robots (some early examples here) would be able to be made in bulk on demand and could help change the entire workflow of device and robot creation, from engineering to warehousing to assembly.
posted by BlackLeotardFront on Apr 3, 2012 - 14 comments

How Corporations Corrupt Science at the Public's Expense

How Corporations Corrupt Science at the Public's Expense: Report looks at methods of corporate abuse, suggests steps toward reform [Full Report (PDF)] [Executive Summary (PDF)] [more inside]
posted by Blasdelb on Mar 11, 2012 - 27 comments

The Science is on a Need-to-know Basis, and You Don't Need to Know

The committee took the unprecedented step of recommending that some details of these biological studies [be] kept from the public, so that no one could use them as recipes for new bioweapons. [more inside]
posted by gauche on Feb 13, 2012 - 30 comments

Some psychotherapy modalities

Here are some evidence-based and research based psychotherapy modalities you may or may not have heard of, a few in the words of their creators: David Burns and CBT and T.E.A.M. Therapy [pdf], Steven Hayes and ACT (also), Marsha Linehan and DBT (also [pdf] and also [pdf]), Joseph Weiss and Control Mastery Theory (also), Eugene Gendlin and Focusing-Oriented Psychotherapy (also).
posted by zeek321 on Dec 28, 2011 - 2 comments

What the heck is research anyway?

What the heck is research anyway?
posted by Blasdelb on Dec 21, 2011 - 38 comments

The importance of stupidity in scientific research

The importance of stupidity in scientific research
posted by Blasdelb on Sep 29, 2011 - 42 comments

Baltimore Lead Study

An experiment done in the 1990s exposed children to various levels of lead. The lawsuit filed in 2001 by the parents of over 100 participants accuses the Kennedy Krieger Institute that the scientists knowingly used the kids as test subjects in toxic dust control study. [more inside]
posted by hat_eater on Sep 19, 2011 - 51 comments

Neuroscience: removing free will since 6th century BC

Does the fact that our brain knows our intentions before we do negate free will? [SLNature]
posted by FrereKhan on Sep 15, 2011 - 172 comments

Water water everywhere

NASA May Have Discovered Flowing Water on Mars Dark, finger-like features appear and extend down some Martian slopes during late spring through summer, fade in winter, and return during the next spring. Repeated observations have tracked the seasonal changes in these recurring features on several steep slopes in the middle latitudes of Mars' southern hemisphere.
posted by modernnomad on Aug 4, 2011 - 65 comments

Science & technology might be exempt from E.U. austerity measures

There is an European Commission budgetary proposal to boost E.U. funding for science and technology by 45% from €55B to €80B by trimming some fat form the controversial Common Agricultural Policy. [more inside]
posted by jeffburdges on Jul 7, 2011 - 6 comments

Neolithic Grog!

The Beer Archaeologist. "Biomolecular archaeologist" Dr. Patrick McGovern has unearthed millennia-old alcohol recipes and ancient medicinals, "by analyzing residues in ancient pottery. Now he's working with brewer Sam Calagione, (of Discovery Channel's Brew Masters, (autoplaying video)) whose pub Dogfish Head serves up beers based on recipes that are thousands of years old." (Via) [more inside]
posted by zarq on Jun 26, 2011 - 45 comments

"Here, eat this root."

The Triumph of New-Age Medicine "Medicine has long decried acupuncture, homeopathy, and the like as dangerous nonsense that preys on the gullible. Again and again, carefully controlled studies have shown alternative medicine to work no better than a placebo. But now many doctors admit that alternative medicine often seems to do a better job of making patients well, and at a much lower cost, than mainstream care—and they’re trying to learn from it." [more inside]
posted by zarq on Jun 15, 2011 - 278 comments

“I’d gladly put my balls on the chopping block for the benefit of mankind.”

The Revolutionary New Birth Control Method for Men. Link NSFW. [more inside]
posted by zarq on May 31, 2011 - 106 comments

Viral link to Chronic Fatigue Syndrome questioned

Editors of the journal Science have asked the co-authors of a 2009 paper that linked chronic fatigue syndrome to a retrovirus called XMRV to voluntarily retract the paper. Science editor-in-chief Bruce Alberts and executive editor Monica Bradford cited concerns about the validity of the findings, saying other scientists hadn't been able to replicate them, among other reasons. [more inside]
posted by Horace Rumpole on May 31, 2011 - 64 comments

Research Blogging

Research Blogging is an aggregator for blog posts on peer-reviewed research. The posts are on various subjects, such as culinary trends in an extinct hominid , the distance and mass of Saggitarius A* and when chemists go to war
posted by Cloud King on May 28, 2011 - 5 comments

A critical moment in statistics

Statistical hypothesis testing with a p-value of less than 0.05 is often used as a gold standard in science, and is required by peer reviewers and journals when stating results. Some statisticians argue that this indicates a cult of significance testing using a frequentist statistical framework that is counterintuitive and misunderstood by many scientists. Biostatisticians have argued that the (over)use of p-vaues come from "the mistaken idea that a single number can capture both the long-run outcomes of an experiment and the evidential meaning of a single result" and identify several other problems with significance testing. XKCD demonstrates how misunderstandings of the nature of the p-value, failure to adjust for multiple comparisons, and the file drawer problem result in likely spurious conclusions being published in the scientific literature and then being distorted further in the popular press. You can simulate a similar situation yourself. John Ioannidis uses problems with significance testing and other statistical concerns to argue, controversially, that "most published research findings are false." Will the use of Bayes factors replace classical hypothesis testing and p-values? Will something else?
posted by grouse on Apr 11, 2011 - 45 comments

master of information

The New Biology - Eric Schadt's quest to upend molecular biology and open source it. (via)
posted by kliuless on Apr 9, 2011 - 35 comments

Chinese Scientific Progress to Overtake American Counterpart Earlier Than Anticipated

According to a new study from the UK's national science academy, the Royal Society, China is on course to outstrip US scientific output as earlier as two years from now. [SLBBC]
posted by modernnomad on Mar 29, 2011 - 37 comments

Greatest land predator ever didn't eat no stinking carrion

No Leftovers for Tyrannosaurus Rex: New Evidence That T. Rex Was Hunter, Not Scavenger [Full text] [more inside]
posted by T.D. Strange on Jan 28, 2011 - 28 comments

get your group on

The Price of Altruism - George Price, a (troubled) father of group selection thru his discovery of the eponymous Price Equation, has a rather interesting biography... [more inside]
posted by kliuless on Jan 15, 2011 - 9 comments

Advance Market Commitments

Inducement Prizes -- Best known for the Ansari X Prize, the DARPA Grand Challenge and the Clay Mathematics Millennium Problems, inducement prizes have a long history, but their recent successes have led to increased government interest, viz. challenge.gov, and resulted in the development of vaccines, thanks in large part to the work of Michael Kremer.* [more inside]
posted by kliuless on Jan 6, 2011 - 8 comments

"the paper could not have been refereed: its correctness is self-evident"

The Line Between Science and Journalism is Getting Blurry….Again by Bora Zivkovic is an excellent, James Burke-ish, essay on science, journalism, and a hopeful future for science journalism. [more inside]
posted by ardgedee on Dec 27, 2010 - 4 comments

Brush your teeth...never?

Scientists at the University of Groningen in The Netherlands have deciphered the structure and functional mechanism of the glucansucrase enzyme that is responsible for dental plaque sticking to teeth. [abstract]
posted by T.D. Strange on Dec 5, 2010 - 30 comments

The Insanity Virus?

New research hints that schizophrenia and other mental illness may be caused by "endogenous retroviruses" stored in our DNA and activated by common infections such as CMV, toxoplamosis, or the flu
posted by T.D. Strange on Nov 12, 2010 - 98 comments

Bell System Technical Journal Archives

The entire run of the Bell System Technical Journal, from 1922-1983, is available online for your reading pleasure. Bell Labs on the blue previously
posted by rmd1023 on Oct 31, 2010 - 21 comments

The fights are so vicious because the stakes are so low.

Sabotage in the lab. "As the problems mounted, Ames was getting agitated. She was certain that someone was monkeying with her experiments, but she had no proof and no suspect. Her close friends suggested that she was being paranoid." Scientific research collides with human nature.
posted by bitmage on Oct 4, 2010 - 64 comments

Jane Goodness

National Geographic has digitized all of Jane Goodall's articles for the publication from the past five decades. They've also added a galley of photographs documenting her extraordinary work with chimps.
posted by gman on Sep 16, 2010 - 12 comments

Arthur's Classic Novels, his Love of Mankind and the Internet

Arthur's Classic Novels has 4000 free ebooks, no registration, nicely organized by author and topics: great old Science Fiction magazines l plentiful online education with 650 books for doctors l a vast collection of famous novels l short stories l by women l Buddhist Scriptures, including The Buddhist Bible, a fave of Jack Kerouac l magazines online l stories by Robert Sheckley l The Autobiography of Charles Darwin l huge collection of fairy tales l philosophy l P. G. Wodehouse l vintage technology l Oscar Wilde l Mark Twain l Rudyard Kipling l George MacDonald l the Koran l a collection of eText resource links. About Arthur Wendover. [more inside]
posted by nickyskye on Sep 16, 2010 - 33 comments

Gingers and daywalkers rejoice!

The human body is made up of more bacteria cells than human cells. Now, researchers at Harvard have isolated the genes responsible for producing amino acids that can block ultraviolet light and managed get E. coli bacteria to produce them too. Can I interest you in some sunblocking bacteria living on your skin?
posted by T.D. Strange on Sep 3, 2010 - 40 comments

Ketamine lifts depression, grows synapses, study says

More research into into the effects of ketamine on depression published today in the journal Science [abstract]. [more inside]
posted by yoHighness on Aug 20, 2010 - 30 comments

The Domestication of Man: The Social Implications of Darwin

New Adventures in Recent Evolution - In the last few years, biologists peering into the human genome have found evidence of recent natural selection. cf. Social Darwinism: 21st century edition [previously] (via ip) [more inside]
posted by kliuless on Jul 20, 2010 - 19 comments

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