Spider webs are incredibly strong and flexible. It’s no surprise, then, that spider silk proteins may someday form durable artificial ligaments for people who have injured their knees or shoulders. Six different kinds of silk are produced by orb-web weaving spiders. These silk fibers have very different mechanical properties that are so effective they have changed very little over millions of years. How to synthetically develop these silks is one focus of Lewis’ research. The secret to producing large quantities of spider silk is to use “factories” designed to manufacture spider silk proteins that are easily scale-able and efficient. Lewis uses transgenic goats, E.coli bacteria, transgenic alfalfa and transgenic silk worms to produce the spider silk proteins used to create spider silk. Spider silk is 100 times stronger than natural ligaments and 10 times stronger than natural tendons; it is stronger than Kevlar and more elastic than nylon.
A 6min brief on the work being done in Laramie, WY whereby spider silk is being spun from goat milk. SPIDERGOATS [more inside]
posted by Blasdelb
on Nov 24, 2013 -
"On a sunny day in 1998, Maura Gillison was walking across the campus of Johns Hopkins University in Baltimore, Maryland, thinking about a virus. The young oncologist bumped into the director of the university's cancer centre, who asked politely about her work. Gillison described her discovery of early evidence that human papillomavirus (HPV) — a ubiquitous pathogen that infects nearly every human at some point in their lives — could be causing tens of thousands of cases of throat cancer each year in the United States. The senior doctor stared down at Gillison, not saying a word. “That was the first clue that what I was doing was interesting to others and had potential significance,” recalls Gillison."
Human papillomavirus is causing a new form of head and neck cancer— leaving researchers scrambling to understand risk factors, tests and treatments. [more inside]
posted by Blasdelb
on Nov 22, 2013 -
The 2013 Lasker Awards were announced today
. Often called the "American's Nobels", they recognize the contributions of scientists, physicians, and public servants who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of human disease. Included in today's crop of recipients are Dr. Graeme M. Clark, Dr. Ingeborg Hochmair, and Blake S. Wilson who were awarded their prizes for developing the modern cochlear implant. [more inside]
posted by scblackman
on Sep 9, 2013 -
More than half the population of small, rural Madras, Oregon (population: ~6059) and its surrounding community is served by one clinic: Madras Medical
. At the beginning of 2006, the clinic's doctors and nurses decided to ban pharmaceutical reps from visiting their practice. No more free lunches. No more free drug samples. No more gifts. And yet.... "It's made us better doctors." (Via) [more inside]
posted by zarq
on Aug 27, 2013 -
What do 3D printing, jelly, liver transplants, chainmail, dental fillings, ferrofluids, and the Six Million Dollar man have to tell us about our future? Materials scientist and engineer Mark Miodownik lets us know in this Royal Institution lecture
posted by cthuljew
on Mar 22, 2013 -
The Norovirus: A Study in Puked Perfection
, "Each norovirus carries just nine protein-coding genes (you have about 20,000). Even with that skimpy genetic toolkit, noroviruses can break the locks on our cells, slip in, and hack our own DNA to make new noroviruses. The details of this invasion are sketchy, alas, because scientists haven’t figured out a good way to rear noroviruses in human cells in their labs. It’s not even clear exactly which type of cell they invade once they reach the gut. Regardless of the type, they clearly know how to exploit their hosts. Noroviruses come roaring out of the infected cells in vast numbers. And then they come roaring out of the body. Within a day of infection, noroviruses have rewired our digestive system so that stuff comes flying out from both ends." [more inside]
posted by Blasdelb
on Jan 3, 2013 -
Association of Coffee Drinking with Total and Cause-Specific Mortality [FULL TEXT HTML]
: "We used data from a very large study, the National Institutes of Health (NIH)–AARP Diet and Health Study
(ClinicalTrials.gov number, NCT00340015
), to determine whether coffee consumption is associated with total or cause-specific mortality. The current analysis, involving more than 400,000 participants and 52,000 deaths, had ample power to detect even modest associations and allowed for subgroup analyses according to important baseline factors, including the presence or absence of adiposity and diabetes, as well as cigarette-smoking status." [more inside]
posted by Blasdelb
on Dec 25, 2012 -
Heaven is Real: A Doctor's Experience of the Afterlife. As a neurosurgeon, I did not believe in the phenomenon of near-death experiences...In the fall of 2008, however, after seven days in a coma during which the human part of my brain, the neocortex, was inactivated, I experienced something so profound that it gave me a scientific reason to believe in consciousness after death.
posted by shivohum
on Oct 12, 2012 -
The drugs don't work
: a modern medical scandal - "The doctors prescribing the drugs don't know they don't do what they're meant to. Nor do their patients. The manufacturers know full well, but they're not telling.
posted by Gyan
on Sep 22, 2012 -
Two-year-old Emma wanted to play with blocks, but a condition called arthrogryposis meant she couldn't move her arms. So researchers at a Delaware hospital 3D printed a durable custom exoskeleton with the tiny, lightweight parts she needed
posted by Foci for Analysis
on Aug 3, 2012 -
"Adrian Owen still gets animated when he talks about patient 23.
The patient was only 24 years old when his life was devastated by a car accident. Alive but unresponsive, he had been languishing in what neurologists refer to as a vegetative state for five years, when Owen, a neuro-scientist then at the University of Cambridge, UK, and his colleagues at the University of Liège in Belgium, put him into a functional magnetic resonance imaging (fMRI) machine and started asking him questions. Incredibly, he provided answers."
posted by jquinby
on Jun 15, 2012 -
The emergence of a citation cartel.
"Cell Transplantation is a medical journal published by the Cognizant Communication Corporation of Putnam Valley, New York. In recent years, its impact factor has been growing rapidly. In 2006, it was 3.482. In 2010, it had almost doubled to 6.204.
When you look at which journals cite Cell Transplantation, two journals stand out noticeably: the Medical Science Monitor, and The Scientific World Journal. According to the JCR, neither of these journals cited Cell Transplantation until 2010.
Then, in 2010, a review article was published in the Medical Science Monitor citing 490 articles, 445 of which were to papers published in Cell Transplantation. All 445 citations pointed to papers published in 2008 or 2009 — the citation window from which the journal’s 2010 impact factor was derived. Of the remaining 45 citations, 44 cited the Medical Science Monitor, again, to papers published in 2008 and 2009.
Three of the four authors of this paper sit on the editorial board of Cell Transplantation. Two are associate editors, one is the founding editor. The fourth is the CEO of a medical communications company."
(from Scholarly Kitchen
, via Andrew Gelman
posted by escabeche
on May 15, 2012 -
In March 2010, a pair of health inspectors responding to multiple tips paid a three-day visit to the factory headquarters of the Poly Implant Prothese
(PIP) company, a leading international maker of breast implants. On their second day, the inspectors found something odd: six discarded plastic containers of Silopren, a liquid silicone designed for industrial, not medical use, lined up along the outside wall of the production site. The lead inspector estimated they had contained nearly 9 tons of liquid silicone. It now appears as if between 300,000 and 400,000 women throughout the world may have received potentially toxic, faulty breast implants containing ingredients never clinically tested on humans, manufactured and distributed by a company that knowingly deceived regulators, suppliers, distributors, medical professionals and ultimately, patients.
Reuters photographer's Blog: Operating on an implant scandal. (Last link NSFW, graphic images that contain nudity.) [more inside]
posted by zarq
on Feb 18, 2012 -
"I'm banned," he says. "By whom?" I ask. "My landlord," he says. "And the Swedish Radiation Safety Authority."
Jon Ronson on DIY science
posted by fearfulsymmetry
on Feb 4, 2012 -
"I would point out to you that medical explanations are modern. That Americans today want medical explanations for things that in the 19th century would have been explained by hysteria, and in the 18th century would have been explained by religious conversion experiences in the context of the Great Awakening, when people were having these types of fits, and in the 17th century by witchcraft."
posted by empath
on Jan 30, 2012 -
Day at Night
was an interview series on the public television station of the City University of New York that aired from 1973-4. CUNY TV is in the process of digitizing and uploading the 130 episodes that were produced, with 46 done so far. The episodes are just under half an hour in length. Among the people interviewed by host James Day are author Ray Bradbury
, actress Myrna Loy
, medical researcher Jonas Salk
, singer Cab Calloway
, writer Christopher Isherwood
, nuclear scientist Edward Teller
, comedian Victor Borge
, tennis player Billie Jean King
, linguist and activist Noam Chomsky
, composer Aaron Copland
, actor Vincent Price
and boxer Muhammad Ali
posted by Kattullus
on Jan 16, 2012 -
: It is common practice for psychiatrists to switch depressive patients between different antidepressants if their current drug does not evince a symptomatic response. Despite clinical wisdom supporting this, little empirical, controlled evidence exists to direct “switching” protocols (e.g. if a patient with Z characteristics is on drug X, is it usually better to switch to drug A, B, or C? Will switching help at all?) in the psychopharmacological treatment of depression. The NIMH-funded STAR*D (Sequenced Alternatives to Relieve Depression) study
aimed to address these questions of treatment direction in a very large (n>4000), “real-world” sample using a multi-phase treatment plan
with different drugs (and cognitive therapy) at every step to maximize chances of eventual remission. Overall, the NIMH reported that about 67% of patients eventually achieved remission
, with few differences in effectiveness between different types of treatment at each step
. However, researchers and commentators have raised concerns
regarding inconsistent reporting of outcomes, after-the-fact changes in study design and analysis
, and other issues that may have inflated, partially invalidated, or misrepresented widely reported treatment outcomes. These inequities may also have implications for the secondary moderator analyses (i.e. does trait A predict switching to X or Y is better?) that were a major reason for the study. [more inside]
posted by Keter
on Jan 14, 2012 -
How can we better understand the interplay of nature and nurture in determining our personalities, behavior, and vulnerability to disease? Perhaps we should be looking at identical twins
. (National Geographic January 2012 cover story) [more inside]
posted by zarq
on Dec 19, 2011 -