"The patient tested negative for HIV, tuberculosis, lime disease, syphilis, coccidioides, histoplasma and cryptococcus." After four years of MRIs, a person's mysterious headaches, seizures and altered sense of smell and memory are diagnosed as a tapeworm growing throughout his brain.
In February 2008, Yehia Gad sequenced Tutankhamun's genes in front of a documentary crew from the Discovery Channel. Jo Marchant writes about the previous work studying his tomb and remians and the unfortunate timing of the last study. (King Tut Previously) [more inside]
The Xenotext Experiment is Christian Bök's [Previously],"nine-year long attempt to create an example of “living poetry.” I have been striving to write a short verse about language and genetics, whereupon I use a “chemical alphabet” to translate this poem into a sequence of DNA for subsequent implantation into the genome of a bacterium (in this case, a microbe called Deinococcus radiodurans—an extremophile, capable of surviving, without mutation, in even the most hostile milieus, including the vacuum of outer space)." [Via] [more inside]
Neandertals are the closest ancestral relatives to modern humans. Today, Nature published a special report on the Neandertal genome, for which a draft sequencing of three billion nucleotides has been completed. This high-throughput sequencing project shows how the genetic relationship between Neandertals and modern Europeans and Asians suggests localized interbreeding between the two species roughly 40-80,000 years ago, complicating the common "out-of-Africa" story of how modern humans originated. Additional research extends this low-coverage, first-pass sequencing with a microarray approach that uncovers specific differences between the human and Neandertal genomes.
I.B.M. Joins Pursuit of $1,000 Personal Genome The target is remarkable given that the original Human Genome Project successfully sequenced the first genome less than ten years ago and cost roughly $500 million to $1 billion. Advances in sequencing technology puts Moore's Law to shame: "In the last four to five years, the cost of sequencing has been falling at a rate of tenfold annually, according to George M. Church, a Harvard geneticist. In a recent presentation in Los Angeles, Dr. Church said he expected the industry to stay on that curve, or some fraction of that improvement rate, for the foreseeable future." [more inside]
How to Sequence a Genome [Flash. H/T to Jay]. Visualization of the process of genetic sequencing. Posted on the Nova website in conjunction with their show, Cracking the Code of Life, hosted by Robert Krulwich [Wiki].
Put down that McChicken sandwich, punk, and back away slowly. OK, now run! The chicken is T. Rex's closest known living relative.