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How to read a paper is a series by Trisha Greenhalgh in BMJ, the British Medical Journal, that explains how to critically read and apply the biomedical literature. Deciding what the paper is about. Assessing methodological quality. Statistics for the non-statistician: parts I and II. Drug trials, diagnostic and screening tests, economic analyses, systematic reviews and meta-analyses (PDF), and qualitative research (PDF).

posted by grouse on Apr 19, 2012 - 14 comments

posted by grouse on Apr 19, 2012 - 14 comments

Statistical hypothesis testing with a p-value of less than 0.05 is often used as a gold standard in science, and is required by peer reviewers and journals when stating results. Some statisticians argue that this indicates a cult of significance testing using a frequentist statistical framework that is counterintuitive and misunderstood by many scientists. Biostatisticians have argued that the (over)use of p-vaues come from "the mistaken idea that a single number can capture both the long-run outcomes of an experiment and the evidential meaning of a single result" and identify several other problems with significance testing. XKCD demonstrates how misunderstandings of the nature of the p-value, failure to adjust for multiple comparisons, and the file drawer problem result in likely spurious conclusions being published in the scientific literature and then being distorted further in the popular press. You can simulate a similar situation yourself. John Ioannidis uses problems with significance testing and other statistical concerns to argue, controversially, that "most published research findings are false." Will the use of Bayes factors replace classical hypothesis testing and p-values? Will something else?

posted by grouse on Apr 11, 2011 - 45 comments

posted by grouse on Apr 11, 2011 - 45 comments

Measure-theoretic probability: Why it should be learnt and how to get started. The clickable chart of distribution relationships. Just two of the interesting and informative probability resources I've learned about, along with countless other tidbits of information, from statistician John D. Cook's blog and his probability fact-of-the-day Twitter feed ProbFact. John also has daily tip and fact Twitter feeds for Windows keyboard shortcuts, regular expressions, TeX and LaTeX, algebra and number theory, topology and geometry, real and complex analysis, and beginning tomorrow, computer science and statistics.

posted by grouse on Dec 5, 2010 - 17 comments

posted by grouse on Dec 5, 2010 - 17 comments

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