Here is Left-Handed Toons (By Right-Handed People), a weekdaily webcomic drawn by two guys, Justin and Drew, using their "off" hands, and with their "off" brains. They have a lot of series. Here's some highlight strips.
Larry Gonick is a veteran American cartoonist best known for his delightful comic-book guides to science and history, many of which have previews online. Chief among them is his long-running Cartoon History of the Universe (later The Cartoon History of the Modern World), a sprawling multi-volume opus documenting everything from the Big Bang to the Bush administration. Published over the course of three decades, it takes a truly global view -- its time-traveling Professor thoroughly explores not only familiar topics like Rome and World War II but the oft-neglected stories of Asia and Africa, blending caricature and myth with careful scholarship (cited by fun illustrated bibliographies) and tackling even the most obscure events with intelligence and wit. This savvy satire carried over to Gonick's Zinn-by-way-of-Pogo chronicle The Cartoon History of the United States, along with a bevy of Cartoon Guides to other topics, including Genetics, Computer Science, Chemistry, Physics, Statistics, The Environment, and (yes!) Sex. Gonick has also maintained a few sideprojects, such as a webcomic look at Chinese invention, assorted math comics (previously), the Muse magazine mainstay Kokopelli & Co. (featuring the shenanigans of his "New Muses"), and more. See also these lengthy interview snippets, linked previously. Want more? Amazon links to the complete oeuvre inside! [more inside]
Romantically Apocalyptic is a morbidly funny webcomic from Russo-Canadian digital artist Vitaly Alexius (interview, gallery). Set in the starkly diaphanous wreckage of post-nuclear Manhattan, it follows an eccentric contingent of Soviet soldiers as they poke through the detritus of the past and contend with the mutants, cultists, aliens, and other horrors that inhabit the ruins. The comic's striking art style is the result of an arduous process, using "Photoshop, live actors, dead actors, sexy assistants, greenscreen, a camera, and a Wacom tablet" to composite "6 years worth of textures: 1 terabyte of stock footage, shot in real abandoned, forgotten places of our world." This multimedia ambition has burgeoned into plans for a community-powered animated/live-action web series (teaser video, animatic, fanart). While waiting for that to come together, be sure to spend some time on Kimmo Lemetti's excellent Gone With the Blastwave (previously), a very similar webcomic project with a more subdued palette that turned out nearly fifty pages of richly-illustrated post-apocalyptic humor before going on indefinite hiatus.
Allie Brosh explains how to put on a coat. Extremely descriptive step by step process on how to put on a coat, complete with cautionary tips, from Hyperbole and a Half's Allie Brosh.
"Hi. My name is Gene and this is my journal." Young Gene Roddenberry meets two Garfield-eyed aliens who proceed to take him everywhere in their exploration of this strange planet Earth. In the process, we see where Gene came up with the idea of a unified borderless, moneyless world that would allow dashing starship captains to seek out new life and new civilizations, boldly going where no one has gone before. We see where Gene first met tribbles, Orion slave girls, Organians, and the Guardian of Forever, and how Gene came up with phasers, tricorders, the Prime Directive, food replicators (from which he orders gagh), Questor androids, and the Enterprise design. [more inside]
Mother fucking bird flu! Asher Sarlin just made me laugh so hard, I think a little bit of poop came out. Be sure to check out Social Studies Fighter II Turbo, nobody needs a venti and what the world would look like if orange juice didn't taste terrible right after you brushed your teeth.
Kill Bill + Harry Potter = Kill Harry, featuring cameo appearances by Bender the robot, Bruce Campbell, and Zombie Rick James, bitch.
Acid Keg is a titter-inducing webcomic that delivers a story of spies, tikis and rock n' roll. Retro done right. The story starts here.