A runner’s high depends on cannabinoid receptors in mice.
October 13, 2015 11:09 AM Subscribe
The Runner’s High: It’s Like Smoking Weed [High Times]
Research on mice [Proceedings of the National Academy of Sciences] has confirmed that a “runner’s high” arises from a release of anandamide, a neurotransmitter that stimulates the same cannabinoid receptors that cannabis does. If you have ever run, biked, lifted weights, or performed any kind of physical exercise, you may have noticed a sense of euphoria and the feeling you are relieved of physical pain and anxiety. They thought it came from β-endorphin, but now scientists have confirmed that anandamide is most likely the cause.
Scientists performed experiments on mice and observed that they displayed fewer symptoms of anxiety and a higher tolerance to pain after running. They then took mice that were genetically engineered to lack endocannabinoid receptors and performed the same experiment. Those mice that had no possibility of getting affected by anandamide, had the similar levels of anxiety and response to pain as mice that did not do any exercise.
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