August 15, 2021

AlphaFold2, RoseTTAFold, and the future of structural biology

Back in 2020, we discussed DeepMind's impressive advances in protein structure prediction, as evinced by their showing at CASP14. They've finally made good on their promise to publish their work on AlphaFold2! In the interim, though, David Baker's group at the University of Washington - perennially one of the top academic groups in the field - got impatient and re-engineered their own protein structure prediction approaches to come up with RoseTTAFold, which appears to be almost as good (and rather less computationally intensive). [more inside]
posted by ASF Tod und Schwerkraft at 8:30 PM PST - 11 comments

Dubai Is A Parody Of The 21st Century

Dubai Is A Parody Of The 21st Century : "The worst of urban planning and capitalism, plus some slavery for good measure. Welcome to Dubai, everyone."
posted by gen at 5:39 PM PST - 56 comments

Just wait until the summer when they let me out the house!

Rumors feat Cardi B is the first new Lizzo track in 2 years!
posted by hippybear at 12:22 PM PST - 27 comments

The homebuyer’s course said always look inside the house before buying

“A block that had once been home to more than 100 people was down to six who lived amid the ruins of another era… And then, for reasons that no one in Peoria could fathom, people from all over America began snapping them up.” (SLWaPo) [more inside]
posted by hwyengr at 9:22 AM PST - 48 comments

"I can't imagine growing up thinking the American dream was real"

F.D Signifier on Bo Burnham's Inside and "White Liberal Performative Art": White Habitus, Performative Wokeness and Existential Dread.
[auto-transcript only]
posted by simmering octagon at 9:20 AM PST - 38 comments

Canadian Federal Election

The writ has dropped. Or... whatever. Less that two years after Canada's last federal election (previously), Prime Minister Justin Trudeau has decided to try converting his minority government into a majority in the middle of a pandemic. [more inside]
posted by clawsoon at 8:26 AM PST - 272 comments

How A “Smart City” Watches You

Whose Streets? Our Streets! 2020-21 “Smart City” Cautionary Trends & 10 Calls to Action to Protect and Promote Democracy. A thorough and well argued exploration of how 'Smart Cities' are eroding privacy, democracy, social justice and freedom.
posted by signal at 7:59 AM PST - 3 comments

“This is their best? Oh.”

Guardian: (on the £38/$53 McCarthy salad) “There are separate sections for chopped beetroot, skinned tomato, bacon minced to a paste, chicken breast with the texture of value-range cotton wool, cubes of sweaty, squeaky cheese, shredded egg and, on top, an avocado that’s been halfway through an egg slicer. Underneath is shredded romaine, including the gnarly hard bit at the centre. That displays serious commitment to gross profit, in all senses.” In which Jay Rayner's commitment to positive restaurant reviews during the pandemic comes to an abrupt end. (Current exchange rate: £1 UK = $1.39 US; previous by JR) [more inside]
posted by Wordshore at 3:20 AM PST - 53 comments

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