Yeah, I get it, this is the internet and we're talking about people eating poop; shame on me for expecting it to be anything other than a huge gag.
The use of human fecal flora to treat gastrointestinal (GI) disorders is not a novel concept, having been practiced periodically for more than 40 years.1 Bacteriotherapy utilizing human feces has been reported to achieve success where antibiotics have failed. While the best known application of bacteriotherapy is in the treatment of unresponsive Clostridium difficile diarrhea and pseudomembranous colitis, 1-10 significant clinical improvements have also been reported in other GI conditions including constipation, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).3,6,11-14
Although the pathogenesis of ulcerative colitis (UC) is unclear, one hypothesis attributes the etiology and persistence of the inflammatory process to the intestinal flora.15,16 Perhaps a viral, bacterial or chemical trigger invokes an overly aggressive host immune response that is perpetuated by the resident flora long after the initial infection has resolved.17-19 Loss of tolerance to the normal luminal contents caused by abnormalities in mucosal permeability or a lack of regulatory cells/mediators is also thought to give rise to chronic inflammation in genetically susceptible individuals.20,21 Given the complex composition of the intestinal flora, it is also feasible that the chronic recurrent inflammation associated with UC is the result of a persistent infection with a specific, but as yet unidentified, pathogen.22,23
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