recent experiments reveal that following days of chronic sleep restriction, signiﬁcant daytime cognitive dysfunction accumulates to levels comparable to that found after severe acute total sleep deprivation. Executive performance functions subserved by the prefrontal cortex in concert with the anterior cingulate and posterior parietal systems seem particularly vulnerable to sleep loss. Following wakefulness in excess of 16 hours, deﬁcits in attention and executive function tasks are demonstrable through well-validated testing protocols.
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