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March 30, 2012 3:47 PM Subscribe
Bombshell investigation reveals vast majority of landmark cancer studies cannot be replicated.
posted by VikingSword (78 comments total)
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In a shocking discovery, C. Glenn Begley, former researcher at Amgen Inc, and a team working with him, has found that 47 out of 53 so called "landmark" basic studies on cancer -- a high proportion of them from university labs -- cannot be replicated, with grim consequences for producing new medicines in the future. These were papers in top journals, from reputable labs, which achieved landmark status with frequent citations. The consequences for cancer research are far-reaching.
The War On Cancer has been puzzlingly slow, with few treatments that can be called break-through. 'The failure to win "the war on cancer" has been blamed on many factors, from the use of mouse models that are irrelevant to human cancers to risk-averse funding agencies. But recently a new culprit has emerged: too many basic scientific discoveries, done in animals or cells growing in lab dishes and meant to show the way to a new drug, are wrong.'
Wrong incentives, pressure to publish, but also fraud are involved.