Of 30 fertilizations achieved after ooplasm transfer from fresh oocytes, 13 pregnancies were reported . Two fetuses were karyotypically 45, XO (Turner’s syndrome). One of these fetuses aborted spontaneously and the other pregnancy was terminated. It is unknown whether a connection exists between these reported aneuploidies and the ooplasm transfer procedure.
To date, over 30 ooplasmic transplantation cases have been completed at the Institute of Reproductive Medicine and Science at Saint Barnabas. The resulting 30 cases had normal fertilization and pregnancy rates with the following outcomes: 1 miscarriage, 11 singletons, 1 twin, and 1 quadruplet birth (Barritt 2000a and Brenner 2000). The first trimester spontaneous miscarriage was diagnosed as 45, XO karyotype (Barritt 2001a and Barritt 2001b), which is the most common aneuploidy associated with intracytoplasmic sperm injection (ICSI). Additionally, the twin pregnancy resulted in a female diagnosed as normal 46, XX with a chromosomally abnormal (45, XO) twin, who was also diagnosed with a form of autism called pervasive disorder. While the incidence rate of chromosomal abnormalities (1/17 or 5.9%) was in the upper range of that normally reported in the New York region (1–6%), an increased aneuploidy rate is commonly observed following ICSI and/or with advanced maternal age. Obviously the sample size was too small to draw any concrete conclusions.
Dr. Mitalipov presented his work at the meeting, and some participants asked whether he had tried to create a real-life environment that would be typical for a pregnant woman.
“What kind of diet did you have these monkeys on?” said Dr. David L. Keefe, a professor in the department of obstetrics and gynecology at New York University School of Medicine. “Did you have them on a McDonald’s super-size stress test?”
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