Serotonin (5-HT) is most commonly thought of as a neurotransmitter in the central nervous system. However, the predominant site of serotonin synthesis, storage, and release is the enterochromaffin cells of the intestinal mucosa.
The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications
Intestinal commensal bacteria or their products may be used to treat CNS disorders.
There is growing interest in the ability of the intestinal microbiome to influence host function within and beyond the gastrointestinal tract. Here we review evidence of microbiome–brain interactions in mice and focus on the ability to transfer behavioral traits between mouse strains using fecal microbiota transplantation (FMT). Transplantation alters brain chemistry and behavior in recipient ex-germ free mice, raising the possibility of using FMT for disorders of the central nervous system, and prompting caution in the selection of FMT donors for conditions that may include refractory Clostridium difficile infection, diabetes and inflammatory bowel disease in humans.
•Behavioral phenotype can be transferred via the intestinal microbiota in mice.
•Changes in behavior in recipient mice are accompanied by changes in brain chemistry.
•Investigation of the intestinal microbiome in central nervous system (CNS) disorders is warranted.
•Donor screening for fecal transplants should exclude CNS and psychiatric illness.
"OnT: I'm seriously considering a probiotic diet. Any recommendations?"
"Yogurts like Dannon’s Activia have been marketed with much success as a panacea for all of our intestinal ills."
New research presented at a scientific meeting adds to a growing body of evidence that a toxin produced by a common food bug may trigger multiple sclerosis, an inflammatory disease of the central nervous system ...
"New research presented at a scientific meeting adds to a growing body of evidence that a toxin produced by a common food bug may trigger multiple sclerosis, an inflammatory disease of the central nervous system ..."
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